Sun Yung-Shin
Department of Physics, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Comput Math Methods Med. 2018 Feb 22;2018:3829768. doi: 10.1155/2018/3829768. eCollection 2018.
Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients. Alternating electric fields with frequencies of 100300 kHz and magnitudes of 13 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells. Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution. In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations. For simplicity, a direct-current electric field was used in the simulation. The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated. Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.
肿瘤治疗电场（TTFields）与化疗和/或放疗联合应用，已在临床上报道可延长胶质母细胞瘤患者的总生存期。频率为100300kHz、强度为13V/cm的交变电场通过与分裂细胞内的极性分子相互作用，显示出可抑制癌细胞生长。由于难以直接测量脑内电场，人体头部的仿真模型为预测电场分布提供了有用工具。在本研究中，构建了一个由头皮、颅骨、硬脑膜、脑脊液和脑组成的三维有限元头部模型，以研究在各种施加电位和电极配置下的电场分布。为简化起见，模拟中使用了直流电场。还评估了不同头部组织中焦耳热导致的总功率耗散和温度升高。基于这些结果，在设计个性化胶质母细胞瘤电疗的电极配置时获得了一些指导原则。
