新诊断的1型糖尿病患者自体混合淋巴细胞反应缺陷
Defective autologous mixed leukocyte reaction in newly diagnosed type 1 diabetes mellitus.
作者信息
Räsänen L, Hyöty H, Lehto M, Kallioniemi O P, Antonen J, Huupponen T, Karjalainen J, Leinikki P
机构信息
Department of Biomedical Sciences, University of Tampere, Finland.
出版信息
Clin Exp Immunol. 1988 Mar;71(3):470-4.
We studied autologous mixed leukocyte reaction (AMLR) in type 1 (insulin-dependent) diabetes mellitus (IDDM) patients, their healthy siblings and healthy schoolchildren, Blood samples from the patients were drawn within 1 week after hospitalization and 2 months later. AMLR was significantly depressed in the patients when compared to healthy siblings or other healthy controls. In addition, the mean AMLR responsiveness of the healthy control group exceeded that of healthy siblings. The production of IL-2 in AMLR was impaired in the patient group and the defective AMLR could be restored by addition of exogenous IL-2 in 7-10 patient cultures. However, in 3-10 patients addition of IL-2 induced no enhancement of proliferation. While the patients in general had raised levels of activated T lymphocytes these three patients had higher numbers of activated T cells than other patients. Defective AMLR and presence of activated T cells may be related and may play a role in the pathogenesis of IDDM.
我们研究了1型（胰岛素依赖型）糖尿病（IDDM）患者、他们健康的兄弟姐妹以及健康学童的自体混合淋巴细胞反应（AMLR）。患者的血样在住院后1周内及2个月后采集。与健康的兄弟姐妹或其他健康对照相比，患者的AMLR明显受到抑制。此外，健康对照组的平均AMLR反应性超过了健康的兄弟姐妹。患者组中AMLR中白细胞介素-2（IL-2）的产生受损，在7 - 10例患者培养物中添加外源性IL-2可恢复有缺陷的AMLR。然而，在3 - 10例患者中添加IL-2并未诱导增殖增强。虽然总体上患者活化T淋巴细胞水平升高，但这3例患者的活化T细胞数量高于其他患者。有缺陷的AMLR与活化T细胞的存在可能相关，并且可能在IDDM的发病机制中起作用。
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