人类白细胞抗原-Dw1和B因子F作为多发性硬化症的保护性标志物。

HLA-Dw1 and BfF as protective markers in multiple sclerosis.

作者信息

Ilonen J, Lagerstedt A, Koskimies S, Reunanen M

出版信息

J Neuroimmunol. 1983 Dec;5(3):283-8. doi: 10.1016/0165-5728(83)90048-6.

Abstract

The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied. SS genotype was found in 76% of MS patients and 63% of control subjects (n.s.) F types (FS + FF) were found to be strongly associated with HLA-Dw1 in control subjects (P less than 0.0014), whereas neither SS nor F containing types were associated with Dw2. The findings support the concept of a hypothetical MS resistance factor in the HLA gene area.

摘要

在54例多发性硬化症患者和58例健康对照者中研究了备解素因子B同种异型的频率，并进一步研究了各种表型与HLA - Dw1和Dw2抗原的关联（分别在多发性硬化症患者中发现频率降低和升高）。在76%的多发性硬化症患者和63%的对照者中发现了SS基因型（无显著性差异）。在对照者中发现F型（FS + FF）与HLA - Dw1强烈相关（P小于0.0014），而含SS或F的类型均与Dw2无关。这些发现支持了HLA基因区域中存在一种假设的多发性硬化症抵抗因子的概念。