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富血小板血浆与骨移植治疗骨内缺损的有效性：一项临床影像学研究。

Effectiveness of Platelet Rich Plasma and Bone Graft in the Treatment of Intrabony Defects: A Clinico-radiographic Study.

作者信息

Jalaluddin Mohammad, Mahesh Jayachandran, Mahesh Rethi, Jayanti Ipsita, Faizuddin Mohamed, Kripal Krishna, Nazeer Nazia

机构信息

Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India.

Department of Periodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India.

出版信息

Open Dent J. 2018 Feb 12;12:133-154. doi: 10.2174/1874210601812010133. eCollection 2018.

DOI:10.2174/1874210601812010133
PMID:29682091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5883369/
Abstract

BACKGROUND & OBJECTIVES: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment and alveolar bone around the affected tooth. Different modalities have been employed in the treatment and regeneration of periodontal defects which include the use of bone grafts, PRP and other growth factors.The purpose of this prospective, randomized controlled study was to compare the regenerative efficacy of PRP and bonegraft in intrabony periodontal defects.

METHODOLOGY

This randomized control trial was carried out in the Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences and Hospital, KIIT University, Bhubaneswar. The study sample included 20 periodontal infrabony defects in 20 patients, 12 males and 8 females. The patients were aged between 25 -45 years(with mean age of 35 years). The 20 sites selected for the study were was randomly divided into 2 groups of 10 sites each. Group A PRP alone, Group B Bone Graft.

STATISTICAL ANAYSIS & RESULTS STATISTICAL ANALYSIS WAS DONE USING SPSS VERSION 180: Statistical analysis was done usingpaired 't' tests and ANOVA that revealed a significant reduction ingingival index, plaque index, probing pocket depth and gain in clinical attachment level at various time intervalswithin both the groups. Radiographic evaluation revealed statistically significant defect fill (<0.001) at the end of 6months within both the groups. However, there was astatistically significant difference seen in group B radiographically, when compared to group A.

CONCLUSION

Both the groups showed promising results in enhancing periodontal regeneration; however the resultswith bonegraftwere comparatively better, although not statistically significant when compared to PRP alone.

摘要

背景与目的

牙周病的特征是存在牙龈炎症、牙周袋形成、结缔组织附着丧失以及患牙周围牙槽骨吸收。牙周缺损的治疗和再生采用了不同的方法，包括使用骨移植、富血小板血浆（PRP）和其他生长因子。这项前瞻性随机对照研究的目的是比较PRP和骨移植治疗骨内牙周缺损的再生效果。

方法

这项随机对照试验在布巴内斯瓦尔KIIT大学卡林加牙科学院和医院的牙周病与口腔种植科进行。研究样本包括20例患者的20个牙周骨下缺损，其中男性12例，女性8例。患者年龄在25 - 45岁之间（平均年龄35岁）。为该研究选择的20个部位随机分为两组，每组10个部位。A组仅使用PRP，B组使用骨移植。

统计分析与结果

使用SPSS 18.0版进行统计分析：采用配对“t”检验和方差分析进行统计分析，结果显示两组在不同时间间隔时牙龈指数、菌斑指数、探诊深度均显著降低，临床附着水平均有提高。影像学评估显示两组在6个月时均有统计学意义的骨缺损填充（<0.001）。然而，与A组相比，B组在影像学上有统计学意义的差异。

结论

两组在促进牙周再生方面均显示出良好的效果；然而，骨移植的效果相对较好，尽管与单独使用PRP相比无统计学意义。

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8
The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis.自体血小板浓缩物在冠向推进瓣治疗牙龈退缩中的附加作用：系统评价和荟萃分析。
Biomed Res Int. 2019 Jul 25;2019:2587245. doi: 10.1155/2019/2587245. eCollection 2019.
富血小板血浆对牙周骨内缺损手术治疗临床疗效的影响：一项系统评价与Meta分析。
BMC Oral Health. 2016 Aug 17;16(1):71. doi: 10.1186/s12903-016-0261-5.
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Platelet-Rich Plasma in the Animal Long-Bone Model: An Analysis of Basic Science Evidence.动物长骨模型中的富血小板血浆：基础科学证据分析
Orthopedics. 2015 Dec;38(12):e1079-90. doi: 10.3928/01477447-20151120-04.
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Platelet-rich plasma for periodontal regeneration in the treatment of intrabony defects: a meta-analysis on prospective clinical trials.富血小板血浆用于治疗骨内缺损的牙周再生：前瞻性临床试验的荟萃分析
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov;120(5):562-74. doi: 10.1016/j.oooo.2015.06.035. Epub 2015 Jul 8.
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Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes.富含血小板血浆对使用无机牛骨矿物质和膨体聚四氟乙烯膜治疗的骨内缺损愈合的影响。
J Periodontol. 2007 Jun;78(6):983-90. doi: 10.1902/jop.2007.060349.
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Combined use of platelet-rich plasma and bone grafting with or without guided tissue regeneration in the treatment of anterior interproximal defects.富血小板血浆与骨移植联合应用，伴或不伴引导组织再生技术治疗前牙邻面缺损。
J Periodontol. 2007 May;78(5):801-9. doi: 10.1902/jop.2007.060318.
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Effect of platelet-rich plasma on the healing of intra-bony defects treated with a natural bone mineral and a collagen membrane.富含血小板血浆对使用天然骨矿物质和胶原膜治疗的骨内缺损愈合的影响。
J Clin Periodontol. 2007 Mar;34(3):254-61. doi: 10.1111/j.1600-051X.2006.01044.x. Epub 2007 Jan 25.
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Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: a comparative controlled clinical study.富血小板血浆联合多孔羟基磷灰石移植物治疗人类骨内牙周缺损：一项对照临床研究。
J Periodontol. 2005 Jun;76(6):890-8. doi: 10.1902/jop.2005.76.6.890.
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A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans.一项关于使用牛多孔骨矿物质、引导组织再生术和富血小板血浆对人类骨内缺损进行再生治疗的再入研究。
Int J Periodontics Restorative Dent. 2005 Feb;25(1):49-59.