Gerova-Vatsova Tsvetalina
Periodontology and Dental Implantology, Medical University of Varna, Varna, BGR.
Cureus. 2024 Oct 30;16(10):e72686. doi: 10.7759/cureus.72686. eCollection 2024 Oct.
Context and objective The main goal of periodontal therapy is to remove periodontopathogenic microorganisms and regenerate destructured periodontal tissues. Advances in biomaterials have improved the results of regenerative procedures. However, there is limited data available to determine the best material for vertical bone deformities treated with regenerative treatment. Studies on autogenous platelet-rich plasma (PRP) have been conducted, but it is often combined with other biomaterials. The objective of this study is to examine the exact efficacy of solely administering autogenous PRP in regenerative therapy of vertical bone defects. Materials and methods The study was conducted from August 2022 to July 2023 at the Faculty of Dental Medicine, Medical University Varna, BGR, using the University Medical and Dental Center as its base. It includes 12 cases with bipartite, tripartite, or a combination of the listed vertical bone defects. Participating patients met the following criteria: signed informed consent; age between 18 and 65 years; individuals in good health without diagnosed systemic disease, and adequate dental care. The clinical parameters investigated and recorded immediately before regenerative therapy with autogenous PRP and six months after the surgical intervention were probing depth, margo gingivalis level, clinical attachment level, and cone beam computed tomography (CBCT)-indicators A (the distance from the cemento-enamel junction to the bottom of the bone defect), B (the distance from the cemento-enamel junction to the apex of the bone defect), and C (the width of the defect). The results obtained from the measurements immediately before the regenerative therapy with PRP and six months after the surgical intervention were compared and analyzed. Results and conclusions The clinical outcomes for vertical bone defects at the six-month mark following the PRP therapy showed an average 3.83 mm reduction in probing depth, an average 0.08 mm coronal migration of the gingival margin, and an average 3.92 mm gain of the clinical level of attachment. The CBCT showed bone filling, which is supported by the average decrease for points A, B, and C of 1.69 mm, 0.51 mm, and 0.36 mm, respectively. The study's findings primarily illustrate the strong potential of autogenous PRP as an independently applicable substance for regeneration therapy in periodontology.
牙周治疗的主要目标是清除牙周致病微生物并使结构破坏的牙周组织再生。生物材料的进展改善了再生治疗的效果。然而，关于确定用于再生治疗垂直骨缺损的最佳材料的可用数据有限。已对自体富血小板血浆（PRP）进行了研究，但它通常与其他生物材料联合使用。本研究的目的是检验单纯应用自体PRP在垂直骨缺损再生治疗中的确切疗效。
本研究于2022年8月至2023年7月在保加利亚瓦尔纳医科大学牙医学院进行，以大学医学与牙科中心为基地。研究包括12例二分、三分或所列垂直骨缺损组合的病例。参与研究的患者符合以下标准：签署知情同意书；年龄在18至65岁之间；身体健康，未诊断出全身性疾病，且有足够的口腔护理。在使用自体PRP进行再生治疗前及手术干预后6个月立即调查并记录的临床参数包括探诊深度、牙龈缘水平、临床附着水平以及锥形束计算机断层扫描（CBCT）指标A（从牙骨质-釉质界到骨缺损底部的距离）、B（从牙骨质-釉质界到骨缺损顶端的距离）和C（缺损宽度）。比较并分析PRP再生治疗前及手术干预后6个月测量所得的结果。
PRP治疗后6个月时垂直骨缺损的临床结果显示，探诊深度平均减少3.83 mm，牙龈缘平均向冠方迁移0.08 mm，临床附着水平平均增加3.92 mm。CBCT显示有骨填充，这分别由A、B、C点平均减少1.69 mm、0.51 mm和0.36 mm得到证实。该研究结果主要表明自体PRP作为牙周病再生治疗中一种可独立应用的物质具有强大潜力。
