Zhu Jing Xuan, Ding Lijian, He Shan
a Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center , Ningbo University , Ningbo , China.
b Key Laboratory of Marine Biotechnology of Zhejiang Province , Ningbo University , Ningbo , China.
Nat Prod Res. 2019 Apr;33(8):1191-1195. doi: 10.1080/14786419.2018.1465423. Epub 2018 Apr 23.
Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.
添加组蛋白脱乙酰酶抑制剂辛二酰苯胺异羟肟酸（SAHA）培养海洋来源的杂色曲霉MCCC 3A00080，显著提高了次级代谢产物的多样性。从处理过的培养物中分离出一种新的联苯衍生物，命名为杂色曲霉醇A（1），以及两种已知化合物，2,4-二甲氧基苯酚（2）和二蒽酚（3）。通过光谱分析并与文献数据比较确定了1-3的结构。在分离出的化合物中，杂色曲霉醇A（1）对金黄色葡萄球菌生长表现出适度抑制作用，MIC值为8μg/mL。
