通过对海洋来源真菌杂色曲霉进行表观遗传操作发现一种新的联苯衍生物。
Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor.
作者信息
Zhu Jing Xuan, Ding Lijian, He Shan
机构信息
a Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center , Ningbo University , Ningbo , China.
b Key Laboratory of Marine Biotechnology of Zhejiang Province , Ningbo University , Ningbo , China.
出版信息
Nat Prod Res. 2019 Apr;33(8):1191-1195. doi: 10.1080/14786419.2018.1465423. Epub 2018 Apr 23.
Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.
添加组蛋白脱乙酰酶抑制剂辛二酰苯胺异羟肟酸（SAHA）培养海洋来源的杂色曲霉MCCC 3A00080，显著提高了次级代谢产物的多样性。从处理过的培养物中分离出一种新的联苯衍生物，命名为杂色曲霉醇A（1），以及两种已知化合物，2,4-二甲氧基苯酚（2）和二蒽酚（3）。通过光谱分析并与文献数据比较确定了1-3的结构。在分离出的化合物中，杂色曲霉醇A（1）对金黄色葡萄球菌生长表现出适度抑制作用，MIC值为8μg/mL。
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