Xu Xiuli, Yang Haijin, Xu Huitao, Yin Liyuan, Chen Zhengkun, Shen Huihui
a School of Ocean Sciences , China University of Geosciences , Beijing , China.
Nat Prod Res. 2018 Apr;32(7):821-825. doi: 10.1080/14786419.2017.1363754. Epub 2017 Aug 22.
One new diphenyl ether, diorcinol K (1), along with three known compounds, diorcinols D (2), F (3) and I (4) were isolated from the fermentation media of a marine-derived fungus Aspergillus sp. CUGB-F046 which was isolated from a sediment sample collected from the Bohai Sea, China. Their structures were elucidated by detailed spectroscopic methods. Compounds 1, 2 and 4 displayed significant antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with MIC values of 3.125, 6.25 and 6.25 μg/mL, respectively.
从一株源自中国渤海沉积物样本中分离得到的海洋真菌曲霉属菌株Aspergillus sp. CUGB-F046的发酵培养基中，分离出一种新的二苯醚——二间苯二酚K（1），以及三种已知化合物二间苯二酚D（2）、F（3）和I（4）。通过详细的光谱方法阐明了它们的结构。化合物1、2和4对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌显示出显著的抗菌活性，其最小抑菌浓度（MIC）值分别为3.125、6.25和6.25μg/mL。
