鼻硬结病患者T淋巴细胞亚群的改变。
Alterations in the T-lymphocyte subpopulation in patients with rhinoscleroma.
作者信息
Berron P, Berron R, Ortiz-Ortiz L
机构信息
Department of Immunology, Universidad Nacional Autonoma de Mexico, Mexico City.
出版信息
J Clin Microbiol. 1988 May;26(5):1031-3. doi: 10.1128/jcm.26.5.1031-1033.1988.
Abstract
T-lymphocyte subpopulations were studied in a group of patients with rhinoscleroma due to Klebsiella rhinoscleromatis. The data demonstrated that these patients had a significantly greater number of T-suppressor/cytotoxic lymphocytes than did clinically healthy individuals. This finding correlated with a diminished response to the T-cell mitogen concanavalin A. The evidence indicated that the T-cell response of these patients was decreased and may reflect the host's response to the bacterial invader, thus explaining the chronicity of the disease.
摘要
对一组因鼻硬结克雷伯菌引起鼻硬结病的患者的T淋巴细胞亚群进行了研究。数据表明，这些患者的T抑制/细胞毒性淋巴细胞数量明显多于临床健康个体。这一发现与对T细胞有丝分裂原刀豆球蛋白A的反应减弱相关。证据表明，这些患者的T细胞反应降低，这可能反映了宿主对细菌入侵者的反应，从而解释了该疾病的慢性病程。
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本文引用的文献
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J Laryngol Otol. 1983 Jan;97(1):55-7. doi: 10.1017/s0022215100093804.
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Bactericidal activity of serum for Klebsiella rhinoscleromatis: studies on serum from a patient with rhinoscleroma and sera deficient in antibody or complement.血清对鼻硬结克雷伯菌的杀菌活性：对一名鼻硬结病患者的血清以及缺乏抗体或补体的血清的研究。
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Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings.免疫学的当前概念：免疫应答的调节——人类中的诱导性和抑制性T淋巴细胞亚群。
N Engl J Med. 1980 Aug 14;303(7):370-3. doi: 10.1056/NEJM198008143030704.
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J Laryngol Otol. 1984 May;98(5):475-9. doi: 10.1017/s0022215100146924.
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7
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