Stiernberg C M, Clark W D
Laryngoscope. 1983 Jul;93(7):866-70. doi: 10.1288/00005537-198307000-00003.
Rhinoscleroma is a rare chronic granulomatous infection predominantly affecting the upper respiratory tract. The patient presented here exemplifies several features of the disease, including the fact that diagnosis may elude the clinician for years, and this delay may increase morbidity substantially. The most common initial complaint is nasal obstruction, and physical examination frequently reveals erythematous granular or nodular swellings covered with crusts. Its tumor-like appearance and local spread arouses suspicion of malignancy, but differential diagnosis also includes fungal infections and numerous granulomatous diseases. The classic histopathology consists of large vacuolated Mikuliz's cells and transformed plasma cells with Russell bodies. Numerous antibiotics have been used for treatment of this infection with varying degrees of success. Long-term follow-up is important because these patients can have numerous relapses. Geographic distribution is also discussed.
鼻硬结病是一种罕见的慢性肉芽肿性感染，主要影响上呼吸道。本文介绍的患者体现了该疾病的几个特征，包括临床医生可能多年都无法做出诊断，而这种延迟可能会大幅增加发病率。最常见的初始症状是鼻塞，体格检查常发现覆盖有痂皮的红斑性颗粒状或结节状肿胀。其肿瘤样外观和局部扩散引发了对恶性肿瘤的怀疑，但鉴别诊断还包括真菌感染和多种肉芽肿性疾病。典型的组织病理学表现为含有大空泡的米库利奇细胞和带有拉塞尔小体的转化浆细胞。许多抗生素已被用于治疗这种感染，取得了不同程度的成功。长期随访很重要，因为这些患者可能会多次复发。本文还讨论了其地理分布情况。
