From the Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut (Drs Bahar and Tormey); and the Pathology and Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, Connecticut (Dr Tormey).
Arch Pathol Lab Med. 2018 May;142(5):662-667. doi: 10.5858/arpa.2016-0620-RS.
Transfusion-associated graft-versus-host disease (TA-GVHD) is a disease with a very high mortality rate. In this report, we discuss TA-GVHD from a historical perspective, highlight the pathogenesis of TA-GVHD, and emphasize the importance of blood product irradiation, which is a very effective means to prevent this disease. We summarize the current recommendations in different patient populations from different countries and review recent developments, such as alternatives for the use of radioactive materials. We also speculate on future directions.
输血相关移植物抗宿主病（TA-GVHD）是一种死亡率非常高的疾病。本报告从历史角度探讨 TA-GVHD，重点介绍 TA-GVHD 的发病机制，并强调血液制品辐照的重要性，这是预防这种疾病的非常有效的手段。我们总结了不同国家不同患者人群的当前建议，并回顾了最近的发展，如放射性物质替代物的应用。我们还对未来的方向进行了推测。
