Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Clinic of Preventive Dentistry, Periodontology and Cariology, Division of Oral Microbiology and Immunology, Center of Dental Medicine; University of Zurich, Zurich, Switzerland.
Am J Pathol. 2018 Jul;188(7):1517-1523. doi: 10.1016/j.ajpath.2018.03.009. Epub 2018 Apr 22.
Streptococcal necrotizing fasciitis (NF) causes high morbidity and mortality despite state-of-the-art therapy. Low incidence and rapid disease progression, necessitating immediate initiation of therapy, have proven challenging aspects for setting up prospective randomized trials. This has resulted in little therapeutic progress over the past decade. The validation of reliable murine NF models to study both pathogenesis and optimized therapeutic regimens of streptococcal NF are thus essential. In this study, we characterized a murine NF model and compared the pathology with an in-depth tissue analysis of streptococcal NF in patients. We found that the streptococcal murine NF model closely reflected all histologic characteristics encountered in human streptococcal NF. This murine NF model helps understanding of human NF pathology better in a time-dependent manner and will allow studying novel therapeutic options in the future.
链球菌坏死性筋膜炎（NF）尽管采用了最先进的治疗方法，但仍具有较高的发病率和死亡率。发病率低且疾病进展迅速，需要立即开始治疗，这给前瞻性随机试验的设置带来了挑战。这导致在过去十年中治疗进展甚微。因此，验证可靠的用于研究链球菌 NF 的发病机制和优化治疗方案的啮齿动物 NF 模型是至关重要的。在这项研究中，我们描述了一种啮齿动物 NF 模型，并将其病理学与对患者中链球菌 NF 的深入组织分析进行了比较。我们发现，链球菌啮齿动物 NF 模型很好地反映了人类链球菌 NF 中遇到的所有组织学特征。这种啮齿动物 NF 模型有助于更好地、随时间推移地了解人类 NF 病理学，并将允许未来研究新的治疗选择。
