Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.
Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), UTAD, Vila Real, Portugal; Faculty of Veterinary Medicine, Lusophone University of Humanities and Technologies, Lisbon, Portugal.
Life Sci. 2018 Jun 15;203:210-224. doi: 10.1016/j.lfs.2018.04.014. Epub 2018 Apr 30.
Prostate cancer is the second most common cancer in men, affecting approximately 1.1 million men worldwide. In this way, the study of prostate cancer biopathology and the study of new potential therapies is of paramount importance. Several rat models were developed over the years to study prostate cancer, namely spontaneous models, chemically-induced models, implantation of cancer cell lines and genetically-engineered models. This manuscript aimed to provide the readers with an overview of the rat models of prostate cancer, highlighting their advantages and disadvantages, as well as, their applications.
前列腺癌是男性第二大常见癌症，全球约有 110 万男性受到影响。因此，前列腺癌的生物病理学研究和新的潜在治疗方法的研究至关重要。多年来，已经开发了几种大鼠模型来研究前列腺癌，即自发性模型、化学诱导模型、癌细胞系植入和基因工程模型。本文旨在为读者提供前列腺癌大鼠模型的概述，强调它们的优缺点及其应用。
