Área de Patología, Decanato de Ciencias Veterinarias, Universidad Centroccidental "Lisandro Alvarado", UCLA, Lara, Venezuela; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.
Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, UTAD, Vila Real, Portugal.
Life Sci. 2017 Mar 15;173:116-134. doi: 10.1016/j.lfs.2017.02.004. Epub 2017 Feb 8.
Mammary cancer is one of the most common cancers, victimizing more than half a million of women worldwide every year. Despite all the studies in this field, the current therapeutic approaches are not effective and have several devastating effects for patients. In this way, the need to better understand the mammary cancer biopathology and find effective therapies led to the development of several rodent models over years. With this review, the authors intended to provide the readers with an overview of the rat models used to study mammary carcinogenesis, with a special emphasis on chemically-induced models.
乳腺癌是最常见的癌症之一，每年在全球范围内使超过 50 万名女性受害。尽管在该领域进行了所有研究，但目前的治疗方法并不有效，并且对患者有几种破坏性的影响。因此，需要更好地了解乳腺癌的生物病理学并找到有效的治疗方法，这导致了多年来几种啮齿动物模型的发展。通过这篇综述，作者旨在为读者提供用于研究乳腺癌发生的大鼠模型概述，特别强调化学诱导模型。
