Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Environmental Health Engineering, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ecotoxicol Environ Saf. 2018 Aug 30;158:171-181. doi: 10.1016/j.ecoenv.2018.04.023. Epub 2018 Apr 24.
Human impact on the environment leads to the release of many pollutants that produce artificial compounds, which can have harmful effects on the body's endocrine system; these are known as endocrine disruptors (EDs). Nonylphenol (NP) is a chemical compound with a nonyl group that is attached to a phenol ring. NP-induced HAX is a sensitive genotoxic biomarker for detecting possible DNA damage; it also causes male infertility and carcinogenesis. We attempt to comprehensively review all the available evidence about the different ways with descriptive mechanisms for explaining the possible DNA damage that is induced by NP. We systematically searched several databases, including PubMed, Scopus, Web of Science, and gray literature, such as Google Scholar by using medical subheading (MeSH) terms and various combinations of selected keywords from January 1970 to August 2017. The initial search identified 62,737 potentially eligible studies; of these studies, 33 were included according to the established inclusion criteria. Thirty-three selected studies, include the topics of animal model (n = 21), cell line (n = 6), human model (n = 4), microorganisms (n = 1), solid DNA (n = 1), infertility (n = 4), apoptosis (n = 6), and carcinogenesis (n = 3). This review highlighted the possible deleterious effects of NP on DNA damage through the ability to produce ROS/RNS. Finally, it is significant to observe caution at this stage with the continued use of environmental pollutants such as NP, which may induce DNA damage and apoptosis.
人类活动对环境的影响导致许多污染物的释放，这些污染物产生人工化合物，可能对人体内分泌系统造成有害影响；这些被称为内分泌干扰物 (EDs)。壬基酚 (NP) 是一种具有壬基基团的化学化合物，连接在苯酚环上。NP 诱导的 HAX 是一种敏感的遗传毒性生物标志物，可用于检测可能的 DNA 损伤；它还会导致男性不育和致癌作用。我们试图全面审查所有关于 NP 可能引起的不同方式和描述性机制的现有证据，以解释可能的 DNA 损伤。我们系统地搜索了几个数据库，包括 PubMed、Scopus、Web of Science 和灰色文献，如 Google Scholar，使用医学主题词 (MeSH) 术语和从 1970 年 1 月到 2017 年 8 月选定关键字的各种组合。初步搜索确定了 62737 项潜在合格的研究；其中，根据既定的纳入标准，有 33 项研究被纳入。33 项选定的研究包括动物模型 (n=21)、细胞系 (n=6)、人体模型 (n=4)、微生物 (n=1)、固体 DNA (n=1)、不育症 (n=4)、细胞凋亡 (n=6)和致癌作用 (n=3)。这篇综述强调了 NP 通过产生 ROS/RNS 的能力对 DNA 损伤的可能有害影响。最后，在现阶段观察到对环境污染物如 NP 的持续使用需保持谨慎是很重要的，因为 NP 可能会引起 DNA 损伤和细胞凋亡。
