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自膨式金属支架是晚期食管癌长期存活者的一种有效选择。

Self-expandable metal stents are a valid option in long-term survivors of advanced esophageal cancer.

作者信息

Rodrigues-Pinto Eduardo, Pereira Pedro, Baron Todd H, Macedo Guilherme

机构信息

Gastroenterology, Centro Hospitalar São João, Portugal.

Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, USA.

出版信息

Rev Esp Enferm Dig. 2018 Aug;110(8):500-504. doi: 10.17235/reed.2018.5323/2017.

Abstract

BACKGROUND

self-expandable metal stents are often used for the palliative treatment of dysphagia in patients with advanced esophageal cancer and an anticipated limited survival. Due to previous reports of a high rate of adverse event when used long-term, concerns have been raised with regard to the use of self-expandable metal stents in patients with a longer survival.

AIM

assess the role of esophageal self-expandable metal stents in patients with advanced esophageal cancer that have survived longer than six months.

METHODS

retrospective study of patients with advanced esophageal cancer with a self-expandable metal stent and a stent placement time greater than six months.

RESULTS

forty-two patients were followed up for 298 days. There was a clinical improvement in all patients. However, 59% of patients experienced an adverse event. The median stent patency was 236 days. Endoscopic management was attempted in all self-expandable metal related adverse events, with a clinical success rate of 100%. However, the previously treated adverse event recurred in seven patients. Multivariate analysis showed that strictures that were traversable with an ultrathin gastroscope were associated with a higher risk of adverse events (p = 0.035).

CONCLUSIONS

long-term esophageal stenting in patients with advanced esophageal cancer is associated with a high prevalence of adverse events without an impact on mortality; most cases can be managed endoscopically.

摘要

背景

自膨式金属支架常用于晚期食管癌吞咽困难患者的姑息治疗,且预期生存期有限。由于既往有长期使用时不良事件发生率较高的报道,对于生存期较长的患者使用自膨式金属支架引发了担忧。

目的

评估食管自膨式金属支架在生存期超过6个月的晚期食管癌患者中的作用。

方法

对置入自膨式金属支架且支架置入时间超过6个月的晚期食管癌患者进行回顾性研究。

结果

42例患者随访298天。所有患者临床症状均有改善。然而,59%的患者发生了不良事件。支架通畅的中位时间为236天。对所有与自膨式金属支架相关的不良事件均尝试进行内镜处理,临床成功率为100%。然而,7例患者既往治疗的不良事件复发。多因素分析显示,可被超薄胃镜通过的狭窄与不良事件风险较高相关(p = 0.035)。

结论

晚期食管癌患者长期食管支架置入与不良事件的高发生率相关,但对死亡率无影响;大多数病例可通过内镜处理。

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