University of Thessaly, School of Health Sciences, Faculty of Medicine, Department of Anesthesiology and Perioperative Medicine, Larisa, Greece; National and Kapodistrian University of Athens, Medical School, Postgraduate Study Program (MSc) "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece.
National and Kapodistrian University of Athens, Medical School, Department of Hygiene, Epidemiology and Medical Statistics, Athens, Greece; European University Cyprus, Department of Health Science & Department of Life Science, Nicosia, Cyprus.
Med Hypotheses. 2018 Jun;115:8-12. doi: 10.1016/j.mehy.2018.03.006. Epub 2018 Mar 20.
Microcirculation is a network of perfused capillaries that connects macrocirculation with the cells. Although research has provided insight into microcirculatory blood flow, our knowledge remains limited. In this article, we propose a new role of microcirculation in physiological and shock states. In healthy individuals, microcirculation maintains cellular homeostasis via preconditioning. When blood volume decreases, the ensuing microcirculatory changes result in heterogeneity of perfusion and tissue oxygenation. Initially, this is partly compensated by the preserved autoregulation and the increase in the metabolism rate of cells, but at later stages, the loss of autoregulation activates the cascade of intracellular hypothermia.
微循环是连接大循环与细胞的充满血液的毛细血管网络。尽管研究已经深入了解微循环血流，但我们的知识仍然有限。在本文中，我们提出了微循环在生理和休克状态中的新作用。在健康个体中，微循环通过预处理维持细胞内稳态。当血容量减少时，随之而来的微循环变化导致灌注和组织氧合的异质性。最初，这部分通过保留的自动调节和细胞代谢率的增加得到补偿，但在后期阶段，自动调节的丧失会激活细胞内低温的级联反应。
