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白细胞介素-10 分泌型树突状细胞-10 是一种独特的工具，可促进耐受抗原特异性 T 调节型 1 细胞。

Interleukin-10-Producing DC-10 Is a Unique Tool to Promote Tolerance Antigen-Specific T Regulatory Type 1 Cells.

机构信息

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) San Raffaele Scientific Institute IRCCS, Milan, Italy.

出版信息

Front Immunol. 2018 Apr 6;9:682. doi: 10.3389/fimmu.2018.00682. eCollection 2018.

DOI:10.3389/fimmu.2018.00682
PMID:29686676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5900789/
Abstract

The prominent role of tolerogenic dendritic cells (tolDCs) in promoting immune tolerance and the development of efficient methods to generate clinical grade products allow the application of tolDCs as cell-based approach to dampen antigen (Ag)-specific T cell responses in autoimmunity and transplantation. Interleukin (IL)-10 potently modulates the differentiation and functions of myeloid cells. Our group contributed to the identification of IL-10 as key factor in inducing a subset of human tolDCs, named dendritic cell (DC)-10, endowed with the ability to spontaneously release IL-10 and induce Ag-specific T regulatory type 1 (Tr1) cells. We will provide an overview on the role of IL-10 in modulating myeloid cells and in promoting DC-10. Moreover, we will discuss the clinical application of DC-10 as inducers of Ag-specific Tr1 cells for tailoring Tr1-based cell therapy, and as cell product for promoting and restoring tolerance in T-cell-mediated diseases.

摘要

耐受性树突状细胞（tolDCs）在促进免疫耐受中的突出作用，以及生成高效临床级产品的方法的发展，使得 tolDCs 可以作为一种基于细胞的方法，用于抑制自身免疫和移植中的抗原（Ag）特异性 T 细胞反应。白细胞介素（IL）-10 可强力调节髓样细胞的分化和功能。我们的研究小组发现 IL-10 是诱导人 tolDC 亚群（称为 DC-10）的关键因素，DC-10 具有自发释放 IL-10 和诱导 Ag 特异性调节性 T 细胞 1（Tr1）的能力。我们将概述 IL-10 在调节髓样细胞和促进 DC-10 中的作用。此外，我们将讨论 DC-10 作为诱导 Ag 特异性 Tr1 细胞的应用，用于定制基于 Tr1 的细胞治疗，以及作为促进和恢复 T 细胞介导疾病中耐受性的细胞产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d0/5900789/897718ff2140/fimmu-09-00682-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d0/5900789/8153363d1aaf/fimmu-09-00682-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d0/5900789/897718ff2140/fimmu-09-00682-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d0/5900789/8153363d1aaf/fimmu-09-00682-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d0/5900789/897718ff2140/fimmu-09-00682-g002.jpg

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