Yu Jea H, Gallemore Esmeralda, Kim Jisoo K, Patel Rocky, Calderon Jorge, Gallemore Ron P
Clinical Research, Retina Macula Institute, 4201 Torrance Boulevard Suite #220, Torrance, CA, United States.
Jules Stein Eye Institute, 1807 Wilshire Blvd #203, Santa Monica, CA, United States.
Am J Ophthalmol Case Rep. 2017 Jul 21;10:142-144. doi: 10.1016/j.ajoc.2017.07.009. eCollection 2018 Jun.
To report the transient resurgence of symptomatic silicone oil droplets following intravitreal bevacizumab injections.
We report seven patients presenting with silicone oil droplets following intravitreal bevacizumab injections. These were the first cases noted in 10 years using the same supplier of preloaded syringes in an estimated 90,413 injections performed by 7 physicians. They occurred during a 4 month period (06-10/2016), suggesting they may have been related to a batch or batches of syringes. Symptomatic floaters attributed to the droplets were noted on an average of 6.7 ± 1.5 days following the injection and followed an average of 10.4 ± 3.75 injections over a period of 3.4 ± 1.9 years and resolved in 5 of our 7 patients within 9 months.
Symptomatic intravitreal silicone oil droplets are a rare complication of intravitreal injections. Symptoms are generally transient and not clinically significant and hence the benefits of treating potentially blinding eye diseases in this fashion appear to outweigh the limited risk of the rare, temporary floaters. The current series may be related to a batch or batches of syringes.
报告玻璃体内注射贝伐单抗后有症状的硅油滴短暂再现情况。
我们报告了7例玻璃体内注射贝伐单抗后出现硅油滴的患者。这是7名医生在估计90413次注射中，使用同一预充式注射器供应商产品的10年里首次记录到的病例。这些病例发生在4个月期间（2016年6月至10月），提示可能与一批或多批注射器有关。注射后平均6.7±1.5天出现归因于这些液滴的有症状飞蚊症，在3.4±1.9年期间平均经过10.4±3.75次注射，7例患者中有5例在9个月内症状消失。
有症状的玻璃体内硅油滴是玻璃体内注射的罕见并发症。症状通常是短暂的，临床上无显著意义，因此以这种方式治疗可能致盲眼病的益处似乎超过了罕见的、暂时飞蚊症的有限风险。目前这一系列病例可能与一批或多批注射器有关。
