Jackson B, Hodsman P, Johnston C I
University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Am J Hypertens. 1988 Jul;1(3 Pt 1):298-300. doi: 10.1093/ajh/1.3.298.
The remnant kidney model of progressive renal failure in the rat was used to assess the relationships between the renin-angiotensin system, exchangeable body sodium, and both plasma concentration and atrial content of atrial natriuretic factor (ANF) measured sequentially over 4 weeks. Following subtotal nephrectomy plasma creatinine (mumol/L) rose from 40 +/- 6 (sham) to 107 +/- 24 (P less than 0.05) at 1 week, and rose further to 124 +/- 20 (P less than 0.05) by 4 weeks. Plasma renin activity (nanograms of angiotensin I/mL/min) rose from 4.5 +/- 0.5 to 11.8 +/- 2.8 (P less than 0.05) at 1 week, but was suppressed by 4 weeks to 2.2 +/- 0.3 (P less than 0.001). Plasma angiotensin II (pg/mL) was 52 +/- 2 (sham), 117 +/- 20 at 1 week (P less than 0.05) and 51.3 at 4 weeks. Exchangeable sodium (mmol/kg) rose progressively from 43.2 +/- 5 (before surgery) to 48.6 +/- 0.9 at 1 week and 50.8 +/- 2.2 at 4 weeks. Plasma atrial natriuretic factor (ANF) (pg/mL) rose progressively from 114 +/- 6 (sham) to 248 +/- 31 (P less than 0.01) at 1 week and 456 +/- 78 at 4 weeks (P less than 0.01). Atrial ANF content fell as the plasma concentration rose. In the remnant kidney model of progressive renal failure there was a progressive increase in exchangeable body sodium and plasma atrial natriuretic factor, with reciprocal changes in atrial ANF content suggesting that ANF secretion rate was increased. Initially the renin-angiotensin system was stimulated, but later it was suppressed.
采用大鼠进行性肾衰竭的残肾模型，以评估肾素 - 血管紧张素系统、可交换体钠与血浆心房利钠因子（ANF）浓度及心房含量之间的关系，这些指标在4周内依次进行测定。肾大部切除术后，血浆肌酐（μmol/L）在1周时从40±6（假手术组）升至107±24（P<0.05），并在4周时进一步升至124±20（P<0.05）。血浆肾素活性（血管紧张素I ng/mL/min）在1周时从4.5±0.5升至11.8±2.8（P<0.05），但在4周时被抑制至2.2±0.3（P<0.001）。血浆血管紧张素II（pg/mL）在假手术组为52±2，1周时为117±20（P<0.05），4周时为51.3。可交换钠（mmol/kg）从手术前的43.2±5逐渐升至1周时的48.6±0.9和4周时的50.8±2.2。血浆心房利钠因子（ANF）（pg/mL）从假手术组的114±6逐渐升至1周时的248±31（P<0.01）和4周时的456±78（P<0.01）。随着血浆浓度升高，心房ANF含量下降。在进行性肾衰竭的残肾模型中，可交换体钠和血浆心房利钠因子逐渐增加，心房ANF含量呈相反变化，提示ANF分泌率增加。最初肾素 - 血管紧张素系统被激活，但随后被抑制。
