结构生物学：Piezo 通过弯曲感知张力。
Structural Biology: Piezo Senses Tension through Curvature.
机构信息
Tsinghua-Peking Joint Center for Life Sciences and Max-Planck Partner Group, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06511, USA.
出版信息
Curr Biol. 2018 Apr 23;28(8):R357-R359. doi: 10.1016/j.cub.2018.02.078.
Abstract
The sensations of sound, touch and pressure are mediated by mechanotransduction channels - transmembrane proteins whose ionic permeabilities are gated by mechanical forces. New structures of Piezo1 by cryoEM lead to the suggestion that this channel might sense membrane tension through changes in the local curvature of the membrane.
摘要
声音、触觉和压力的感觉是由机械转导通道介导的——这些跨膜蛋白的离子通透性由机械力控制。冷冻电镜的 Piezo1 新结构表明，该通道可能通过改变膜的局部曲率来感知膜张力。
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本文引用的文献
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