Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Curr Biol. 2018 Apr 23;28(8):R392-R397. doi: 10.1016/j.cub.2017.12.034.
Tissue wound repair has been studied extensively. It involves the coordinated activation of several intracellular and intercellular pathways, as well as remodeling from the sequential recruitment of different cell types to the wound site. There is, however, an equally important process that happens at the single cell level, when the integrity of the plasma membrane is compromised. Individual eukaryotic cells can rapidly repair their plasma membrane after injury, through a process that restores internal homeostasis and prevents cell death. Despite its importance, investigations of this fascinating mechanism have been limited. Only recently have we begun to understand that plasma-membrane repair resembles tissue healing, in the sense that it also involves sequential, highly localized remodeling steps that ultimately eliminate all traces of the injury.
组织伤口修复已被广泛研究。它涉及几个细胞内和细胞间途径的协调激活，以及从不同细胞类型的顺序募集到伤口部位的重塑。然而，在单细胞水平上，当质膜完整性受到损害时，也会发生一个同样重要的过程。在受到损伤后，单个真核细胞可以迅速通过一个恢复细胞内稳态并防止细胞死亡的过程来修复其质膜。尽管这一过程非常重要，但对这一迷人机制的研究一直受到限制。直到最近，我们才开始了解到质膜修复类似于组织愈合，因为它也涉及顺序的、高度局部化的重塑步骤，最终消除损伤的所有痕迹。
