基于氧化铁-药物纳米笼的治疗一体化纳米复合系统，用于靶向磁场响应化疗。
A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy.
机构信息
Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram (D.T.), Tamilnadu, India.
Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Ireland.
出版信息
Nanomedicine. 2018 Jul;14(5):1643-1654. doi: 10.1016/j.nano.2018.04.013. Epub 2018 Apr 22.
In this work, a theranostic nanocage system was developed for the targeted delivery of the anti-cancer agents camptothecin (CPT) and luotonin A (LuA). The core of the nanocage system (FeO@OA-AD-SP NCs) was formed by biogenically synthesized FeO nanoparticles (NPs) decorated with a model anti-cancer drug (AD) and biosurfactant saponin (SP). The FeO@OA-AD-SP NCs showed a high lipophilic AD loading efficiency (>80%) and a controlled pH-responsive drug release in stimulated cancerous cells in pH 6.4 media buffer. In addition, FeO@OA-AD-SP NCs exhibited better serum protein binding efficacy at physiological pH values (7.4), furthering the important role of SP surface decoration. Particularly, these NCs showed better chemotherapeutic efficacy when examined in MCF-7 and HeLa cancer cell lines with a specific targeting capacity. Therefore, this study provides a new nano platform based on magnetic targeting and pH responsive lipophilic anticancer drug delivery to the cancer site.
在这项工作中，开发了一种治疗性纳米笼系统，用于靶向递抗癌剂喜树碱（CPT）和洛托汀 A（LuA）。纳米笼系统的核心（FeO@OA-AD-SP NCs）由生物合成的 FeO 纳米颗粒（NPs）组成，这些 NPs 用模型抗癌药物（AD）和生物表面活性剂皂素（SP）进行了修饰。FeO@OA-AD-SP NCs 在 pH 值为 6.4 的刺激癌细胞的介质缓冲液中表现出高亲脂性 AD 负载效率（>80%）和受 pH 控制的药物释放。此外，在生理 pH 值（7.4）下，FeO@OA-AD-SP NCs 表现出更好的血清蛋白结合效果，进一步证明了 SP 表面修饰的重要作用。特别是，这些 NCs 在 MCF-7 和 HeLa 癌细胞系中表现出更好的化疗疗效，具有特定的靶向能力。因此，本研究提供了一种基于磁靶向和 pH 响应亲脂性抗癌药物递送至癌症部位的新型纳米平台。
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