Douek Daniel C
Vaccine Research Center of the National Institutes of Health, Bethesda, MD, USA.
Top Antivir Med. 2018 Apr;25(4):121-125.
Achieving cure of HIV infection requires eliminating all replication-competent virus from the reservoir of latently infected cells or completely inhibiting infected cells from emerging from latency. Strategies include very early use of antiretroviral therapy; hematopoietic stem cell transplantation; "shock-and-kill" approaches; immune therapy with immune checkpoint inhibitors; gene therapy, including use of CC chemokine receptor 5-modified CD4+ T cells; and broadly neutralizing antibody therapy. Success is likely to require a combination of approaches. This article summarizes a presentation by Daniel C. Douek, MD, PhD, at the IAS-USA continuing education program held in Berkeley, California, in May 2017.
实现治愈HIV感染需要从潜伏感染细胞库中清除所有具有复制能力的病毒，或完全抑制感染细胞从潜伏状态中复苏。策略包括尽早使用抗逆转录病毒疗法；造血干细胞移植；“激活并清除”方法；使用免疫检查点抑制剂进行免疫治疗；基因治疗，包括使用CC趋化因子受体5修饰的CD4+T细胞；以及广泛中和抗体疗法。成功可能需要多种方法的联合使用。本文总结了医学博士、哲学博士丹尼尔·C·杜埃克于2017年5月在加利福尼亚州伯克利举行的美国国际艾滋病学会继续教育项目上的一次演讲。
