Department of Veterinary Sciences, University of Turin, Largo Braccini 2, 10095, Grugliasco (Torino), Italy.
Center of Rickettsiosis and Arthropod-Borne Diseases, Hospital San Pedro-CIBIR, C/ Piqueras 98, 26006, Logroño, Spain.
Parasit Vectors. 2018 Apr 24;11(1):263. doi: 10.1186/s13071-018-2856-y.
Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered. In this review, we focus on the 'neglected' aspects of tick-borne rickettsioses and on the gaps in knowledge, which could help to explain why these infections are still emerging and re-emerging threats worldwide.
立克次体病是已知最古老的传染病之一。尽管如此，并且已经进行了广泛的研究，但蜱传立克次体的生物学和流行病学的许多方面仍远未被完全理解。它们与节肢动物媒介的关联、脊椎动物作为储存宿主的重要性、动物中临床症状的罕见性，或者病原性物种与立克次体内共生体以及与宿主细胞内环境的相互作用，只是其中的一些例子。此外，不断有新的立克次体被发现。在这篇综述中，我们重点关注蜱传立克次体病被忽视的方面和知识空白，这有助于解释为什么这些感染仍然是全球新出现和再现的威胁。
