评价磁性纳米颗粒对马链球菌产透明质酸的影响。
Evaluation of magnetic nanoparticles influence on hyaluronic acid production from Streptococcus equi.
机构信息
National Institute of Laser Enhanced Sciences, Cairo University, 12613 Giza, Egypt.
Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt; Faculty of Science, Department of Chemistry, Taif University, Taif 21974, Saudi Arabia.
出版信息
Carbohydr Polym. 2018 Jul 15;192:135-142. doi: 10.1016/j.carbpol.2018.03.037. Epub 2018 Mar 19.
This work aims at developing a novel hyaluronic acid (HA) production method using magnetic nanoparticles (NPs). In a separate process, HA was produced with the addition of the amino acids (AA) as bio-additives. Regarding the NPs additives, the results showed that the highest dry weight of the produced HA was 0.264 g/l with the addition of 20 mg/l of FeO NPs. Concerning the AA additives, the results showed that the highest dry weight of the produced HA was 0.079 g/l with the addition of 0.26 g/l of glutamic acid (GA) compared to the control produced 0.065 g/l. These results led to further develop a novel HA production method which is preparing the FeO NPs using GA as stabilizer, where the results showed that dry weight of the produced HA was 0.435 g/l with the addition of 20 mg/l of FeO-GA NPs.
本工作旨在开发一种使用磁性纳米粒子 (NPs) 的新型透明质酸 (HA) 生产方法。在另一个过程中，添加氨基酸 (AA) 作为生物添加剂来生产 HA。关于 NPs 添加剂，结果表明，添加 20mg/L 的 FeO NPs 时，所产生的 HA 的干重最高为 0.264g/L。关于 AA 添加剂，结果表明，添加 0.26g/L 的谷氨酸 (GA) 时，所产生的 HA 的干重最高为 0.079g/L，与对照相比（产生 0.065g/L）。这些结果促使我们进一步开发了一种新型的 HA 生产方法，即使用 GA 作为稳定剂制备 FeO NPs，结果表明，添加 20mg/L 的 FeO-GA NPs 时，所产生的 HA 的干重为 0.435g/L。
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