Hendaus Mohamed A, Alhammadi Ahmed H, Chandra Prem, Muneer Eshan, Khalifa Mohamed S
Department of Pediatrics, Section of Academic General Pediatrics, Hamad General Corporation, Doha, Qatar.
Department of Pediatrics, Section of Academic General Pediatrics, Sidra Medicine, Doha, Qatar.
Int J Gen Med. 2018 Apr 10;11:143-149. doi: 10.2147/IJGM.S154424. eCollection 2018.
Bronchiolitis is considered as the most frequent lower respiratory tract infection in infants and young children. This disorder is marked by acute inflammation, edema, damage of epithelial cells lining small airways, and augmentation of mucus production.
The goal of the study was to identify agents triggering bronchiolitis in the State of Qatar.
A cross-sectional retrospective study was performed at Hamad Medical Corporation, the only tertiary and academic medical center in the State of Qatar. The study included infants and young children aged 0-24 months who were admitted to our pediatric ward with diagnosis of acute bronchiolitis (2010-2012).
Eight hundred thirty-five infants and young children met the study inclusion criteria with mean age at diagnosis of 3.61±3.56 months. Respiratory virus real-time polymerase chain reaction was performed on 769 (92.0%) of the participants. Respiratory syncytial virus (RSV) was positive in 352 (45.7%) children admitted with clinical bronchiolitis. In addition, no viruses were identified in 142 (18.4%) of those admitted, and respiratory viruses other RSV were found in 275 (35.7%) of the children. Our investigations and observations show that there has been a steady and periodic seasonal variation in the RSV rate over the study period. A seasonal trend for the RSV (detected by respiratory virus real-time polymerase chain reaction) rate was evident, showing annual peaks in the months of October, November, December, and January, with a significant test for seasonality (test statistics []=3.15, =0.009).
In countries with desert hot weather, bronchiolitis might affect children throughout the year. Our results suggest that the combination of date regarding uninterrupted RSV seasonality can provide guidance for health care planning and application of RSV prevention scheme, such as extending the palivizumab immunoglobulin series.
细支气管炎被认为是婴幼儿最常见的下呼吸道感染。这种疾病的特征是急性炎症、水肿、小气道内衬上皮细胞受损以及黏液分泌增加。
本研究的目的是确定卡塔尔引发细支气管炎的因素。
在卡塔尔唯一的三级学术医疗中心哈马德医疗公司进行了一项横断面回顾性研究。该研究纳入了2010 - 2012年因急性细支气管炎诊断入住我们儿科病房的0 - 24个月的婴幼儿。
835名婴幼儿符合研究纳入标准，诊断时的平均年龄为3.61±3.56个月。769名（92.0%）参与者进行了呼吸道病毒实时聚合酶链反应检测。352名（45.7%）临床诊断为细支气管炎的患儿呼吸道合胞病毒（RSV）呈阳性。此外，142名（18.4%）入院患儿未检测到病毒，275名（35.7%）患儿检测到除RSV外的其他呼吸道病毒。我们的调查和观察表明，在研究期间RSV感染率存在稳定的周期性季节性变化。RSV（通过呼吸道病毒实时聚合酶链反应检测）感染率呈现明显的季节性趋势，在10月、11月、12月和1月出现年度高峰，季节性检验具有显著性（检验统计量[] = 3.15，P = 0.009）。
在沙漠炎热气候的国家，细支气管炎可能全年影响儿童。我们的结果表明，关于RSV季节性不间断的数据组合可为医疗保健规划和RSV预防方案的应用提供指导，如延长帕利珠单抗免疫球蛋白疗程。
