Kalantari Hamid, Karimzadeh Hadi, Kalantari Saeed, Talebi Majid, Yaran Majid, Golpayegani Javad
Department of Gastroenterology, Liver and Gastrointestinal Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2018 Mar 27;23:22. doi: 10.4103/jrms.JRMS_366_17. eCollection 2018.
Chronic hepatitis type-C virus (HCV) infection is one of the most common worldwide viral disorders, which leads to various clinical complications as well as extrahepatic manifestations. Furthermore, Vitamin D3 has also been reported to have relationship with the mentioned complications. The aim is to evaluate the correlation between Vitamin D3 level and extrahepatic manifestation in chronic HCV patients.
This cross-sectional study has been carried out on 90 patients with chronic hepatitis C. The level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic manifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed.
Most of our patients were male (92% vs. 8%). Twenty-nine percent had the insufficient amount of Vitamin D3 (21-30 ng/ml), and the remains had the Vitamin D3 level between 13-20 ng/ml. Furthermore, our assessment demonstrated that deficiency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confidence interval (CI) 95%] = 8.80 [1.74-44.47], = 0.004), vasculitis (OR [95% CI] = 11.70 [3.01-45.41], < 0.001), arthralgia (OR [95% CI] = 20.26 [4.21-97.47], < 0.001), myalgia (OR [95% CI] = 4.00 [1.01-17.27], = 0.048), and glomerulonephritis ( = 0.021).
According to our results, the extrahepatic manifestation in the patients with sufficient levels of Vitamin D3 would be less possible. In fact, it could be stated that deficiency in the Vitamin D3 can have a significant relationship with these manifestations.
慢性丙型肝炎病毒（HCV）感染是全球最常见的病毒性疾病之一，可导致各种临床并发症以及肝外表现。此外，据报道维生素D3也与上述并发症有关。目的是评估慢性HCV患者维生素D3水平与肝外表现之间的相关性。
对90例慢性丙型肝炎患者进行了这项横断面研究。评估了90例慢性HCV患者血浆中的维生素D3水平。进行了基因分型，并收集了招募患者的临床及体征和症状。评估了肝外表现，并评估了血液、肝脏和免疫因素与维生素D3水平之间的相关性。
我们的大多数患者为男性（92%对8%）。29%的患者维生素D3含量不足（21 - 30 ng/ml），其余患者的维生素D3水平在13 - 20 ng/ml之间。此外，我们的评估表明，维生素D3缺乏与紫癜（优势比[OR][95%置信区间（CI）95%]=8.80[1.74 - 44.47]，P = 0.004）、血管炎（OR[95%CI]=11.70[3.01 - 45.41]，P < 0.001）、关节痛（OR[95%CI]=20.26[4.21 - 97.47]，P < 0.001）、肌痛（OR[95%CI]=4.00[1.01 - 17.27]，P = 0.048）和肾小球肾炎（P = 0.021）等肝外表现相关。
根据我们的结果，维生素D3水平充足的患者出现肝外表现的可能性较小。事实上，可以说维生素D3缺乏与这些表现有显著关系。
