Lee S N, Cho J-Y, Eun Y-M, Song S-W, Moon K-W
a Department of Internal Medicine , St. Vincent's Hospital, The Catholic University of Korea , Suwon , South Korea ;
b Department of Family Medicine , St. Vincent's Hospital, The Catholic University of Korea , Suwon , South Korea.
Climacteric. 2016 Oct;19(5):458-62. doi: 10.1080/13697137.2016.1200550. Epub 2016 Jul 9.
Coronary artery disease (CAD) and osteoporosis are major causes of mortality and morbidity in postmenopausal women. We aimed to investigate the association between osteoporosis and CAD in asymptomatic postmenopausal women at a single center.
This study included 863 postmenopausal women without histories of cardiovascular diseases who visited the Health Promotion Center from June 1, 2004 to May 31, 2015. All subjects were screened for bone mineral density (BMD) by dual-energy X-ray absorptiometry and for the degree of CAD by multidetector computed tomography.
Low BMD including osteopenia and osteoporosis was found to be significantly associated with old age, low body mass index, and a higher prevalence of diabetes mellitus. The incidences of CAD including a high coronary artery calcium score (≥100), obstructive coronary artery disease, and multivessel disease were significantly higher in subjects with low BMD. After adjusting for age and cardiovascular risk factors, osteoporosis was associated with a high coronary artery calcium score (p = 0.015) and with obstructive coronary artery disease (p = 0.002). There was a trend toward significance with multivessel disease (p = 0.052).
High coronary artery calcium score and obstructive coronary artery disease, as revealed by multidetector computed tomography, were associated with osteoporosis in asymptomatic postmenopausal women, independent of cardiovascular risk factors and age.
冠状动脉疾病（CAD）和骨质疏松症是绝经后女性死亡和发病的主要原因。我们旨在研究单一中心无症状绝经后女性中骨质疏松症与CAD之间的关联。
本研究纳入了2004年6月1日至2015年5月31日期间前往健康促进中心就诊、无心血管疾病病史的863名绝经后女性。所有受试者均通过双能X线吸收法进行骨密度（BMD）筛查，并通过多排螺旋计算机断层扫描评估CAD程度。
发现低骨密度（包括骨量减少和骨质疏松症）与老年、低体重指数以及较高的糖尿病患病率显著相关。低骨密度受试者中，CAD的发生率（包括高冠状动脉钙化评分（≥100）、阻塞性冠状动脉疾病和多支血管病变）显著更高。在调整年龄和心血管危险因素后，骨质疏松症与高冠状动脉钙化评分（p = 0.015）和阻塞性冠状动脉疾病（p = 0.002）相关。多支血管病变存在显著趋势（p = 0.052）。
多排螺旋计算机断层扫描显示，高冠状动脉钙化评分和阻塞性冠状动脉疾病与无症状绝经后女性的骨质疏松症相关，独立于心血管危险因素和年龄。
