Masuda T, Ando K, Marumo F
Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Japan.
Neurosci Lett. 1988 May 16;88(1):93-9. doi: 10.1016/0304-3940(88)90321-7.
Atrial natriuretic peptide (ANP) concentrations in the cerebrospinal fluid (CSF) and plasma of canine were 2.1 +/- 1.1 pg/ml (mean +/- S.D.) and 53.1 +/- 21.1 (n = 20), respectively. The regression coefficient between these concentrations was -0.0045 (P = n.s.). The ANP concentration in the CSF did not change even after the plasma ANP concentration was altered following the change of left atrial pressure, as in 4 cases of an experimental aortic regurgitation. Thus, ANP concentration in the CSF is not influenced by ANP concentrations in the plasma at least under our condition. Gel permeation chromatography revealed a single form of ANP in the position of authentic alpha-ANP in canine CSF, while a high molecular weight ANP peak was observed as well as alpha-ANP in the plasma.
犬脑脊液（CSF）和血浆中的心房利钠肽（ANP）浓度分别为2.1±1.1皮克/毫升（平均值±标准差）和53.1±21.1（n = 20）。这些浓度之间的回归系数为-0.0045（P =无显著差异）。在实验性主动脉反流的4例病例中，即使左心房压力改变后血浆ANP浓度发生变化，CSF中的ANP浓度也没有改变。因此，至少在我们的条件下，CSF中的ANP浓度不受血浆中ANP浓度的影响。凝胶渗透色谱法显示犬CSF中真实α-ANP位置有一种单一形式的ANP，而血浆中除了α-ANP外还观察到一个高分子量ANP峰。
