亚硝基（2-氧代丙基）胺诱导KK小鼠脂肪浸润胰腺中的活化导管增生
Activated Ductal Proliferation Induced by -Nitroso (2-oxopropyl)amine in Fat-infiltrated Pancreas of KK- Mice.
作者信息
Hori Mika, Mutoh Michihiro, Ishigamori Rikako, Imai Toshio, Takahashi Mami
机构信息
Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
出版信息
In Vivo. 2018 May-Jun;32(3):499-505. doi: 10.21873/invivo.11267.
BACKGROUND/AIM: Our aim was to investigate whether tissue with fatty infiltration within the lobes of the pancreas (scattered FI) is sensitive to carcinogen-induced pancreatic ductal proliferation.
MATERIALS AND METHODS
Seven-week-old female C57BL/6J, C57BL/6J-A, KK-A, and ICR mice were subcutaneously treated with N-nitrosobis(2-oxopropyl) amine at a dose of 80 mg/kg body weight, and the differences in damage-induced cell proliferation and their biochemical data were compared 2 days after.
RESULTS
Scattered FI in the pancreas was obvious only in KK-A mice, which have high serum lipid, leptin and insulin levels, and cell proliferation both in pancreatic and common bile ducts was enhanced only in KK-A mice by the carcinogen treatment.
CONCLUSION
Scattered FI in the pancreas per se can be an important factor for carcinogenesis. The genetic background causing scattered FI of the pancreas should be further investigated.
背景/目的：我们的目的是研究胰腺叶内有脂肪浸润的组织（散在性脂肪浸润）是否对致癌物诱导的胰腺导管增殖敏感。
材料与方法
对7周龄的雌性C57BL/6J、C57BL/6J-A、KK-A和ICR小鼠皮下注射剂量为80mg/kg体重的N-亚硝基双（2-氧代丙基）胺，并在2天后比较损伤诱导的细胞增殖差异及其生化数据。
结果
胰腺散在性脂肪浸润仅在血清脂质、瘦素和胰岛素水平较高的KK-A小鼠中明显，致癌物处理后仅KK-A小鼠的胰腺和胆总管中的细胞增殖增强。
结论
胰腺散在性脂肪浸润本身可能是致癌的一个重要因素。导致胰腺散在性脂肪浸润的遗传背景应进一步研究。
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