Helgeson A S, Lawson T, Pour P
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):191-7. doi: 10.1016/0742-8413(84)90150-6.
The short- and long-term effects of the administration of the pancreas carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) on pancreatic exocrine secretion were examined in Syrian hamsters with and without stimulation by secretin and pancreozymin. Protein concentration, flow rate, pH and ion content, (Na+, K+, Ca2+, Mg2+, HCO3-, Cl-, HPO4(2-) and SO4(2-)) were measured. An immediate effect of BOP is the stimulation of flow rate in females and of protein secretion in both sexes. Multiple doses of BOP significantly altered the parameters mentioned in Section 2 only in the later stages of tumorigenesis. When these animals were stimulated with secretin or pancreozymin large decreases in flow rate and protein content of secretions were observed as early as 8 weeks after BOP treatment. Insulin-like immunoreactivity and growth hormone-like immunoreactivity were detected in collected pancreatic secretions.
在有或无促胰液素和胰酶泌素刺激的情况下，研究了胰腺致癌物N-亚硝基双（2-氧代丙基）胺（BOP）对叙利亚仓鼠胰腺外分泌的短期和长期影响。测量了蛋白质浓度、流速、pH值和离子含量（Na+、K+、Ca2+、Mg2+、HCO3-、Cl-、HPO4(2-)和SO4(2-)）。BOP的即时效应是刺激雌性的流速和两性的蛋白质分泌。多剂量的BOP仅在肿瘤发生的后期显著改变了第2节中提到的参数。当用促胰液素或胰酶泌素刺激这些动物时，早在BOP治疗后8周就观察到分泌物流速和蛋白质含量大幅下降。在收集的胰腺分泌物中检测到胰岛素样免疫反应性和生长激素样免疫反应性。
