Goriainov Vitali, Hulsart-Billstrom Gry, Sjostrom Terje, Dunlop Douglas G, Su Bo, Oreffo Richard O C
Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom.
Oral and Dental Sciences, University of Bristol, Bristol, United Kingdom.
Front Bioeng Biotechnol. 2018 Apr 11;6:44. doi: 10.3389/fbioe.2018.00044. eCollection 2018.
Despite technological advancements, further innovations in the field of orthopedics and bone regeneration are essential to meet the rising demands of an increasing aging population and associated issues of disease, injury and trauma. Nanotopography provides new opportunities for novel implant surface modifications and promises to deliver further improvements in implant performance. However, the technical complexities of nanotopography fabrication and surface analysis have precluded identification of the optimal surface features to trigger osteogenesis. We herein detail the osteoinductive potential of discrete nanodot and nanowire nanotopographies. We have examined the ability of modified titanium and titanium alloy (Ti64) surfaces to induce bone-specific gene activation and extracellular matrix protein expression in human skeletal stem cells (SSCs) , and osteogenic response within a murine calvarial model . This study provides evidence of enhanced osteogenic response to nanowires 300 surface modifications, with important implications for clinical orthopedic application.
尽管技术不断进步，但骨科和骨再生领域的进一步创新对于满足日益老龄化人口不断增长的需求以及相关的疾病、损伤和创伤问题至关重要。纳米拓扑学为新型植入物表面改性提供了新机会，并有望进一步提高植入物性能。然而，纳米拓扑学制造和表面分析的技术复杂性阻碍了对触发骨生成的最佳表面特征的识别。我们在此详细阐述离散纳米点和纳米线纳米拓扑学的骨诱导潜力。我们研究了改性钛和钛合金（Ti64）表面在人骨骼干细胞（SSCs）中诱导骨特异性基因激活和细胞外基质蛋白表达的能力，以及在小鼠颅骨模型中的成骨反应。本研究提供了对纳米线300表面改性增强成骨反应的证据，对临床骨科应用具有重要意义。
