Matthews Sara J, Picton Helen, Ernst Erik, Andersen Claus Y
The Portland Hospital for Women and Children, London, UK.
Laboratory of Reproductive Biology, Section 5712, University Hospital of Copenhagen, Copenhagen, Denmark.
Minerva Ginecol. 2018 Aug;70(4):432-435. doi: 10.23736/S0026-4784.18.04240-5. Epub 2018 Apr 24.
Ovarian tissue removed from a 9-year-old girl suffering from thalassemia was kept deep-frozen for 14 years before being transplanted back to the now adult woman. Subsequently, she conceived following IVF treatment and delivered a healthy baby where the oocyte derived from the transplanted tissue. This is the first woman worldwide to have a baby where the ovarian tissue was frozen pre-pubertally and expand the therapeutic options for rare genetic diseases like thalassemia and girls who suffer from childhood cancer.
从一名9岁患地中海贫血的女孩身上取出的卵巢组织被深度冷冻了14年，之后被移植回现已成年的该女性体内。随后，她在接受体外受精治疗后怀孕，并产下一名健康婴儿，其卵子来源于移植组织。她是全球首例通过移植青春期前冷冻的卵巢组织而诞下婴儿的女性，这也为地中海贫血等罕见遗传病以及患儿童癌症的女孩拓展了治疗选择。
