排卵后卵母细胞老化过程中的异常赖氨酸乙酰化
Abnormal lysine acetylation with postovulatory oocyte aging.
作者信息
Lee Ah Reum, Thanh Ha Le, Kishigami Satoshi, Hosoi Yoshihiko
机构信息
Division of Biological Science, Graduate School of Biology-Oriented Science and Technology Kinki University 649-6493 Kinokawa Wakayama Japan.
PRESTO, Japan Science and Technology Agency 332-0012 Kawaguchi Saitama Japan.
出版信息
Reprod Med Biol. 2013 Dec 4;13(2):81-86. doi: 10.1007/s12522-013-0172-y. eCollection 2014 Apr.
BACKGROUND
A postovulatory mammalian oocyte decreases developmental potential with in vivo aging in the oviduct or in vitro aging in the culture dish. The mechanism underlying oocyte aging still largely remains an enigma. Accumulating data suggest that the epigenetic alterations such as histone acetylation are also associated with postovulatory aging.
OBJECTIVE
To perform a review evaluating a new aspect of oocyte aging in terms of the epigenetic alterations focusing on lysine acetylation.
METHODS
In addition to a search of the literature in Pubmed, we introduced our recent published data.
RESULTS
Histone acetylation in the mouse oocyte increases during aging, potentially impacting gene regulation in the subsequent embryonic development. Oocyte aging results in increased acetylation of alpha-tubulin, a non-histone protein, and nicotinamide, an inhibitor of class III HDAC, partially prevents some of oocyte aging phenotypes.
CONCLUSION
Abnormal regulation of protein acetylation itself is suggested in oocyte aging and could contribute to the aging phenotypes.
背景
排卵后的哺乳动物卵母细胞，无论是在输卵管中进行体内老化，还是在培养皿中进行体外老化，其发育潜能都会降低。卵母细胞老化背后的机制在很大程度上仍是个谜。越来越多的数据表明，诸如组蛋白乙酰化等表观遗传改变也与排卵后老化有关。
目的
从聚焦赖氨酸乙酰化的表观遗传改变方面，对卵母细胞老化的一个新方面进行综述评估。
方法
除了在PubMed上检索文献外，我们还引入了我们最近发表的数据。
结果
小鼠卵母细胞中的组蛋白乙酰化在老化过程中增加，这可能会影响随后胚胎发育中的基因调控。卵母细胞老化导致非组蛋白α-微管蛋白的乙酰化增加，III类组蛋白去乙酰化酶抑制剂烟酰胺可部分预防一些卵母细胞老化表型。
结论
提示在卵母细胞老化中存在蛋白质乙酰化本身的异常调控，这可能导致老化表型。
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