有丝分裂中微管蛋白的翻译后修饰。
Tubulin post-translational modifications in meiosis.
机构信息
Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda 20892, MD, USA.
出版信息
Semin Cell Dev Biol. 2023 Mar 15;137:38-45. doi: 10.1016/j.semcdb.2021.11.014. Epub 2021 Nov 23.
Abstract
Haploid gametes are produced from diploid parents through meiosis, a process inherent to all sexually reproducing eukaryotes. Faithful chromosome segregation in meiosis is essential for reproductive success, although it is less clear how the meiotic spindle achieves this compared to the mitotic spindle. It is becoming increasingly clear that tubulin post-translational modifications (PTMs) play critical roles in regulating microtubule functions in many biological processes, and meiosis is no exception. Here, I review recent advances in the understanding of tubulin PTMs in meiotic spindles, especially focusing on their roles in spindle integrity, oocyte aging, and non-Mendelian transmission.
摘要
单倍体配子是由二倍体亲本通过减数分裂产生的，减数分裂是所有有性繁殖真核生物所固有的过程。减数分裂中染色体的正确分离对于生殖成功至关重要，尽管与有丝分裂纺锤体相比，减数分裂纺锤体如何实现这一点还不太清楚。越来越明显的是，微管蛋白翻译后修饰（PTMs）在许多生物过程中调节微管功能中起着关键作用，减数分裂也不例外。在这里，我回顾了在理解减数分裂纺锤体中微管蛋白 PTM 方面的最新进展，特别是重点介绍它们在纺锤体完整性、卵母细胞衰老和非孟德尔遗传中的作用。
相似文献
1
Tubulin post-translational modifications in meiosis.有丝分裂中微管蛋白的翻译后修饰。
Semin Cell Dev Biol. 2023 Mar 15;137:38-45. doi: 10.1016/j.semcdb.2021.11.014. Epub 2021 Nov 23.
2
Spindle asymmetry drives non-Mendelian chromosome segregation.纺锤体不对称驱动非孟德尔式染色体分离。
Science. 2017 Nov 3;358(6363):668-672. doi: 10.1126/science.aan0092.
3
HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.HDAC11 通过降低 H4K16 和 α-微管蛋白乙酰化促进小鼠卵母细胞成熟过程中的减数分裂装置组装。
Cell Cycle. 2020 Feb;19(3):354-362. doi: 10.1080/15384101.2019.1711315. Epub 2020 Jan 7.
4
A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes.一种新的微管成核途径，用于卵母细胞减数分裂纺锤体的组装。
J Cell Biol. 2018 Oct 1;217(10):3431-3445. doi: 10.1083/jcb.201803172. Epub 2018 Aug 7.
5
The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis.Esco1 通过乙酰化 α-微管蛋白来建立着丝粒凝聚因子，以确保卵母细胞减数分裂中纺锤体的正确组装。
Nucleic Acids Res. 2018 Mar 16;46(5):2335-2346. doi: 10.1093/nar/gky001.
6
Distinct roles of cohesin acetyltransferases Esco1 and Esco2 in porcine oocyte meiosis I.Esco1 和 Esco2 在猪卵母细胞减数分裂 I 中的作用不同。
Cell Cycle. 2019 Oct;18(19):2481-2494. doi: 10.1080/15384101.2019.1651162. Epub 2019 Aug 6.
7
Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.γ-微管蛋白对于果蝇卵母细胞前期 I 中双极纺锤体的组装以及动粒微管的正确附着是必需的。
PLoS Genet. 2011 Aug;7(8):e1002209. doi: 10.1371/journal.pgen.1002209. Epub 2011 Aug 11.
8
Oocyte Meiotic Spindle Assembly and Function.卵母细胞减数分裂纺锤体的组装与功能。
Curr Top Dev Biol. 2016;116:65-98. doi: 10.1016/bs.ctdb.2015.11.031. Epub 2016 Jan 23.
9
Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis.人类卵母细胞减数分裂过程中微管蛋白翻译后修饰及其酶的表征
Reprod Biomed Online. 2025 Mar;50(3):103885. doi: 10.1016/j.rbmo.2024.103885. Epub 2024 Feb 9.
10
Spindle formation and dynamics of gamma-tubulin and nuclear mitotic apparatus protein distribution during meiosis in pig and mouse oocytes.猪和小鼠卵母细胞减数分裂过程中纺锤体形成以及γ-微管蛋白和核有丝分裂器蛋白的分布动态
Biol Reprod. 2000 May;62(5):1184-92. doi: 10.1095/biolreprod62.5.1184.
引用本文的文献
1
Spindle checkpoint can secure additional cheating time for selfish expanded centromeres.纺锤体检查点可以为自私扩展的着丝粒确保额外的作弊时间。
Curr Biol. 2025 Jul 8. doi: 10.1016/j.cub.2025.06.056.
2
Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes.烟酰胺单核苷酸生物合成与F-肌动蛋白细胞骨架调控排卵后老化猪卵母细胞的纺锤体组装和卵母细胞成熟质量。
Cell Commun Signal. 2025 Apr 17;23(1):186. doi: 10.1186/s12964-025-02200-4.
3
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets.微管蛋白乙酰转移酶通过紫杉烷结合口袋中的锚定物接近并修饰微管腔内侧的赖氨酸40残基。
Nat Struct Mol Biol. 2025 Feb;32(2):358-368. doi: 10.1038/s41594-024-01406-3. Epub 2024 Nov 4.
4
Elevated N-glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging.N-糖基化组织蛋白酶L水平升高会损害卵母细胞功能，并导致生殖衰老过程中的卵母细胞衰老。
Aging Cell. 2025 Feb;24(2):e14397. doi: 10.1111/acel.14397. Epub 2024 Nov 4.
5
Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis.驱动蛋白 KIFC3 对于卵母细胞减数分裂中微管的稳定性和胞质分裂是必需的。
Cell Commun Signal. 2024 Mar 29;22(1):199. doi: 10.1186/s12964-024-01589-8.
6
C-Type Natriuretic Peptide Pre-Treatment Improves Maturation Rate of Goat Oocytes by Maintaining Transzonal Projections, Spindle Morphology, and Mitochondrial Function.C型利钠肽预处理通过维持透明带投影、纺锤体形态和线粒体功能提高山羊卵母细胞的成熟率。
Animals (Basel). 2023 Dec 16;13(24):3880. doi: 10.3390/ani13243880.
7
Physiological roles of chloride ions in bodily and cellular functions.氯离子在身体和细胞功能中的生理作用。
J Physiol Sci. 2023 Nov 15;73(1):31. doi: 10.1186/s12576-023-00889-x.
8
Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation.微管蛋白的翻译后修饰：乙酰化难以捉摸的作用
Biology (Basel). 2023 Apr 6;12(4):561. doi: 10.3390/biology12040561.
9
The Male Mouse Meiotic Cilium Emanates from the Mother Centriole at Zygotene Prior to Centrosome Duplication.合子期前，雄性小鼠减数分裂中心粒纤毛从母中心粒发出，此时中心体尚未复制。
Cells. 2022 Dec 29;12(1):142. doi: 10.3390/cells12010142.
本文引用的文献
1
Initial spindle positioning at the oocyte center protects against incorrect kinetochore-microtubule attachment and aneuploidy in mice.初始纺锤体定位在卵母细胞中心可防止小鼠中不正确的着丝粒-微管附着和非整倍体。
Sci Adv. 2023 Feb 17;9(7):eadd7397. doi: 10.1126/sciadv.add7397.
2
Microtubule organizing centers regulate spindle positioning in mouse oocytes.微管组织中心调控小鼠卵母细胞中纺锤体的定位。
Dev Cell. 2022 Jan 24;57(2):197-211.e3. doi: 10.1016/j.devcel.2021.12.011. Epub 2022 Jan 13.
3
Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation.区分有丝分裂和减数分裂：染色体、细胞骨架与细胞周期调控之间的相互作用
Front Cell Dev Biol. 2021 Apr 8;9:660322. doi: 10.3389/fcell.2021.660322. eCollection 2021.
4
Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes.PLK1 和 Aurora A 在小鼠精母细胞减数分裂中心体生物发生过程中的重叠作用。
EMBO Rep. 2021 Apr 7;22(4):e51023. doi: 10.15252/embr.202051023. Epub 2021 Feb 21.
5
Mechanisms of meiotic drive in symmetric and asymmetric meiosis.在对称和不对称减数分裂中的减数分裂驱动机制。
Cell Mol Life Sci. 2021 Apr;78(7):3205-3218. doi: 10.1007/s00018-020-03735-0. Epub 2021 Jan 15.
6
Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.微管糖基化控制轴丝动力蛋白的活性、鞭毛的拍打和雄性的生育能力。
Science. 2021 Jan 8;371(6525). doi: 10.1126/science.abd4914.
7
Lysine acetylation of cytoskeletal proteins: Emergence of an actin code.细胞骨架蛋白赖氨酸乙酰化：肌动蛋白密码的出现。
J Cell Biol. 2020 Dec 7;219(12). doi: 10.1083/jcb.202006151.
8
The Tubulin Code in Microtubule Dynamics and Information Encoding.微管动力学与信息编码中的微管编码。
Dev Cell. 2020 Jul 6;54(1):7-20. doi: 10.1016/j.devcel.2020.06.008.
9
Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species.内在微管动态特性的差异导致了非洲爪蟾物种纺锤体长度的控制。
Curr Biol. 2020 Jun 8;30(11):2184-2190.e5. doi: 10.1016/j.cub.2020.03.067. Epub 2020 May 7.
10
The tubulin code and its role in controlling microtubule properties and functions.微管蛋白密码及其在控制微管性质和功能中的作用。
Nat Rev Mol Cell Biol. 2020 Jun;21(6):307-326. doi: 10.1038/s41580-020-0214-3. Epub 2020 Feb 27.
Zotero 插件