Matsumoto Hiromichi, Sato Eimei
Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai and.
Department of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi, Japan.
Reprod Med Biol. 2006 May 19;5(2):81-86. doi: 10.1007/BF03016143. eCollection 2006 Jun.
Increased uterine vascular permeability and angiogenesis are hallmarks of implantation and placentation. These events are profoundly influenced by vascular endothelial growth factor (VEGF). Although VEGF and its receptor Flk-1 are primarily important for uterine vascular permeability and angiogenesis before and during the attachment phase of the implantation process, VEGF together with the angiopoietins and their receptor Tie-2 directs angiogenesis during decidualization after implantation. Uterine expression of HIF and ARNT follows the localization of VEGF expression with increasing angiogenesis during the postimplantation period, although their expression does not correlate with VEGF expression during the pre-implantation period. Upstream of VEGF, estrogen promotes uterine vascular permeability but inhibits angiogenesis, whereas progesterone stimulates angiogenesis with little effect on vascular permeability. Furthermore, COX-2-derived prostaglandins participate in uterine vascular permeability and angiogenesis during implantation and decidualization. (Reprod Med Biol 2006; : 81-86).
子宫血管通透性增加和血管生成是着床和胎盘形成的标志。这些过程受到血管内皮生长因子（VEGF）的深刻影响。尽管VEGF及其受体Flk-1在着床过程的附着期之前和期间对子宫血管通透性和血管生成至关重要，但VEGF与血管生成素及其受体Tie-2一起在着床后蜕膜化期间指导血管生成。在着床后时期，随着血管生成增加，低氧诱导因子（HIF）和芳香烃受体核转运蛋白（ARNT）的子宫表达遵循VEGF表达的定位，尽管它们在着床前期的表达与VEGF表达不相关。在VEGF上游，雌激素促进子宫血管通透性但抑制血管生成，而孕酮刺激血管生成，对血管通透性影响很小。此外，环氧化酶-2（COX-2）衍生的前列腺素在着床和蜕膜化期间参与子宫血管通透性和血管生成。（《生殖医学与生物学》2006年；：81 - 86）
