Kramer Frank, Just Steffen, Zeller Tanja
Department of Medical Statistics, University Medical Center Göttingen, Humboldtallee, 32, Göttingen, Germany.
Molecular Cardiology, Department of Medicine II, University of Ulm, Ulm, Germany.
BMC Syst Biol. 2018 Apr 25;12(1):57. doi: 10.1186/s12918-018-0579-5.
Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions.
In this review, we provide an overview of the current molecular-experimental, epidemiological and bioinformatical tools applied in systems medicine in the cardiovascular field. We will discuss the status and challenges in implementing interdisciplinary systems medicine approaches in CVD.
心血管疾病（CVD）是全球发病和死亡的最重要原因之一。增进对CVD发病基础理解的创新方法有望加强CVD风险评估，并可能为个性化治疗铺平道路。在过去几年中，系统医学已成为研究基因、分子和生理相互作用的新型工具。
在本综述中，我们概述了目前在心血管领域系统医学中应用的分子实验、流行病学和生物信息学工具。我们将讨论在CVD中实施跨学科系统医学方法的现状和挑战。
