Department of Neurology, Rigshospitalet-Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark.
University of Copenhagen, Copenhagen, Denmark.
J Neurol. 2018 Dec;265(12):2755-2763. doi: 10.1007/s00415-018-8869-9. Epub 2018 Apr 26.
BACKGROUND/AIMS: The prevalence of overweight/obesity is a major problem in the world, and the number of MS cases is increasing. This literature study examines the relationship between overweight/obesity in children and adolescents and later occurrence of MS.
This is a complete literature survey. The search database is primarily Pubmed using MeSH terms "multiple sclerosis", "obesity", and "overweight", and text words not to restrict searches.
All included studies show a link between being overweight/obese and the presence of MS among people below 20 years of age. The relation is especially true for young girls. The same relation in boys is not significant.
The literature survey convincingly revealed a link between young overweight/obese and occurrence of MS, in particular for girls. There is a need for more and larger studies to investigate the molecular mechanisms that link obesity and MS.
背景/目的：超重/肥胖的流行是全球的一个主要问题，多发性硬化症（MS）的病例数正在增加。本文献研究探讨了儿童和青少年超重/肥胖与日后发生 MS 的关系。
这是一项完整的文献综述。使用 MeSH 术语“多发性硬化症”、“肥胖”和“超重”以及非限定性搜索的文本词，主要在 Pubmed 数据库中进行搜索。
所有纳入的研究都表明超重/肥胖与 20 岁以下人群中 MS 的发生之间存在关联。这种关联在年轻女孩中尤为明显。男孩中则没有显著的相关性。
文献综述令人信服地揭示了年轻超重/肥胖与 MS 发生之间的联系，特别是对于女孩。需要进行更多更大规模的研究，以探究肥胖与 MS 之间的关联的分子机制。
