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Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation.系统评价和荟萃分析议定书的首选报告项目（PRISMA-P）2015：详细说明和解释。
BMJ. 2015 Jan 2;350:g7647. doi: 10.1136/bmj.g7647.
2
Effect of banxiaxiexin tang on treatment of functional dyspepsia: a meta-analysis of randomized controlled trials.半夏泻心汤治疗功能性消化不良的疗效：一项随机对照试验的荟萃分析。
J Tradit Chin Med. 2014 Apr;34(2):140-4. doi: 10.1016/s0254-6272(14)60067-4.
3
Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application.胃肠道疾病的汉方药：基础科学和临床证据的综述及其未来应用。
J Gastroenterol. 2013 Apr;48(4):452-62. doi: 10.1007/s00535-013-0788-z. Epub 2013 Mar 16.
4
[Updated guidelines 2012 for gastroesophageal reflux disease].[2012年胃食管反流病更新指南]
Korean J Gastroenterol. 2012 Oct;60(4):195-218. doi: 10.4166/kjg.2012.60.4.195.
5
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.评估卫生保健干预措施的研究的系统评价和Meta分析报告的PRISMA声明：解释与详述。
PLoS Med. 2009 Jul 21;6(7):e1000100. doi: 10.1371/journal.pmed.1000100.
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Usage of supplemental alternative medicine by community-based patients with gastroesophageal reflux disease (GERD).
Dig Dis Sci. 2002 Jan;47(1):1-8. doi: 10.1023/a:1013264730992.
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Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial.胃食管反流病药物和手术治疗的长期疗效：一项随机对照试验的随访
JAMA. 2001 May 9;285(18):2331-8. doi: 10.1001/jama.285.18.2331.
8
Bias in meta-analysis detected by a simple, graphical test.通过一种简单的图形检验检测荟萃分析中的偏倚。
BMJ. 1997 Sep 13;315(7109):629-34. doi: 10.1136/bmj.315.7109.629.

半夏泻心汤治疗胃食管反流病：一项对照试验系统评价方案

Banxia Xiexin tang for gastro-oesophageal reflux disease: A protocol for a systematic review of controlled trials.

作者信息

Kang Bohyung, Lee Haesol, Choi Youkyung, Jeon Chanyong, Lee Ju Ah

机构信息

Department of Korean Internal Medicine, College of Korean Medicine, Gachon University.

出版信息

Medicine (Baltimore). 2018 Apr;97(17):e0393. doi: 10.1097/MD.0000000000010393.

DOI:10.1097/MD.0000000000010393
PMID:29702986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5944504/
Abstract

BACKGROUND

Gastrooesophageal reflux disease (GORD) is one of the most common gastrointestinal diseases encountered in clinical practice. The aim of the present study is thus to systematically review the literature, including Asian studies, to assess the efficacy and safety of Banxia Xiexin tang (BXT) for the treatment of GORD.

METHODS AND ANALYSIS

Eleven databases will be searched for studies conducted through March 2018. We will include randomized controlled trials (RCTs) of BXT as a treatment for GORD. All RCTs on BXT or related formulations will be included. The risk of bias will be assessed using the Cochrane Risk of Bias Assessment Tool, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool.

ETHICS AND DISSEMINATION

This systematic review will be published in a peer-reviewed journal and will also be disseminated electronically and in print. The review will be updated to inform and guide healthcare practices.

REGISTRATION NUMBER

CRD42018087056.

摘要

背景

胃食管反流病（GORD）是临床实践中最常见的胃肠道疾病之一。因此，本研究的目的是系统回顾文献，包括亚洲地区的研究，以评估半夏泻心汤（BXT）治疗GORD的有效性和安全性。

方法与分析

将检索11个数据库，查找截至2018年3月开展的研究。我们将纳入BXT治疗GORD的随机对照试验（RCT）。所有关于BXT或相关制剂的RCT均将纳入。将使用Cochrane偏倚风险评估工具评估偏倚风险，同时使用推荐分级、评估、制定与评价（GRADE）工具评估累积证据的可信度。

伦理与传播

本系统评价将发表在同行评审期刊上，也将以电子和印刷形式传播。该评价将进行更新，为医疗实践提供信息和指导。

注册号

CRD42018087056。