Pevny I, Hutzler D
Dermatologischen Klinik und Poliklinik, Universität Würzburg.
Derm Beruf Umwelt. 1988 May-Jun;36(3):91-8.
We carried out patch testing with a chinoline block comprising 25 substances in 316 patients with a suspected allergy to chinoline derivatives in the period from February 1969 to December 1983. 110 patients reacted to 2 or more substances. The reactions were totaled and tabulated in a list indicating frequency of sensitisation as decreasing in the order of Cl-F-Br-I halogens. The most frequent reactions observed were with Chlorisept, Sterosan, Vio-form, Chinosol, Ondron, and Broxychinolin, for all of which primary sensitisations are also possible. Concomitant reactions to chinaldol, chinaldine, aminochinaldine and chinoline are considered to be group allergies since contact is hardly possible with these substances in everyday life. Due to the lack of appropriate history, reactions to Resochin and the isoquinoline compounds Papaverine and Eupaverine may also be regarded as group allergies. Accordingly, non-hydroxylized chinoline derivatives are also viewed as group allergies in cases of sensitisation to hydroxy-chinoline derivatives. The group spectrum of hydroxy-chinoline allergy seems to be more far-reaching than was assumed. Five cases of a quinine allergy identified by appropriate history and confirmed epicutaneously are presented with a group allergy to various chinoline derivatives, including two cases with quinidine.
1969年2月至1983年12月期间，我们对316例疑似对喹啉衍生物过敏的患者进行了含25种物质的喹啉阻滞斑贴试验。110例患者对2种或更多种物质有反应。将反应汇总并列表，按Cl-F-Br-I卤素的顺序列出致敏频率递减情况。观察到最常见的反应是对氯己定、氯己定碘、甲紫、氯甲酚、安多霖和溴喹啉的反应，所有这些物质都可能引起原发性致敏。对喹哪啶、喹哪啶红、氨基喹哪啶和喹啉的伴随反应被认为是群体性过敏，因为在日常生活中几乎不可能接触到这些物质。由于缺乏适当的病史，对氯喹和异喹啉化合物罂粟碱及优帕曲班的反应也可能被视为群体性过敏。因此，在对羟基喹啉衍生物致敏的情况下，非羟基化喹啉衍生物也被视为群体性过敏。羟基喹啉过敏的群体谱似乎比预期的更广泛。本文报告了5例经适当病史确认并经皮证实的奎宁过敏病例，伴有对各种喹啉衍生物的群体性过敏，其中包括2例奎尼丁过敏病例。
