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[异烟酸新型氨基酸衍生物的嗜神经及嗜心性特性]

[The neurotropic and cardiotropic properties of new amino acid derivatives of isonicotinic acid].

作者信息

Samvelian V M, Kazarian S A, Matevosian L A, Dzhanpoladian E G, Khoetsian E L, Mndzhoian O L

出版信息

Eksp Klin Farmakol. 1992 Mar-Apr;55(2):11-3.

PMID:1330144
Abstract

Different derivatives of isonicotinic acid are used widely enough as antimicrobial and antituberculous agents. However, their neurotropic and cardiotropic effects have been studied little. The paper is concerned with investigations of these types of the activity of the new derivatives of isonicotinic acid: beta-phenyl-beta-alanine, l-proline, DL-valine, beta-alanine and DL-threonine synthesized for the first time at the Institute of Fine Organic Chemistry, Academy of Sciences of Armenia.

摘要

异烟酸的不同衍生物作为抗菌和抗结核药物被广泛使用。然而,它们的神经亲和性和心脏亲和性作用却鲜有研究。本文关注的是对异烟酸新衍生物的这些活性类型的研究:β-苯基-β-丙氨酸、L-脯氨酸、DL-缬氨酸、β-丙氨酸和DL-苏氨酸,这些是亚美尼亚科学院精细有机化学研究所首次合成的。

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