Tiurenkov I N
Farmakol Toksikol. 1983 Jan-Feb;46(1):54-9.
It was established in acute and chronic experiments on cats that phenibut ethers are 7-10 times more potent than phenibut itself as regards hypotensive activity and produce inconsistent effects on the cardio- and hemodynamics. Of these ethers, methyl ether of phenibut is the most powerful agent. It causes lasting hypotension when given in doses of 1/50 and 1/30 of the LD50 at the cost of a decrease in the general peripheral resistance. At the same time, apart from raising the blood inflow to the heart and cardiac output, the drug has a compensated adverse ino- and chronotropic action on the heart.
通过对猫进行的急性和慢性实验确定，在降压活性方面，苯乙胺醚的效力比苯乙胺本身强7至10倍，并且对心脏和血液动力学产生不一致的影响。在这些醚类中，苯乙胺甲醚是最有效的药物。当以LD50的1/50和1/30的剂量给药时，它会导致持久的低血压，代价是全身外周阻力降低。同时，除了增加心脏的血液流入和心输出量外，该药物对心脏有代偿性的不良变力性和变时性作用。
