Dourish C T, Clark M L, Iversen S D
Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
Psychopharmacology (Berl). 1988;95(2):185-8. doi: 10.1007/BF00174507.
There have been recent claims that the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicits chewing and eating of solid but not liquid foods. Therefore, the effects of 8-OH-DPAT and another 5-HT1A agonist gepirone on the consumption of a liquid chow diet, by free feeding male rats, were examined. Both drugs produced a dose-dependent increase in the consumption of liquid diet during a 2 h test. The doses of 8-OH-DPAT and gepirone which increased liquid diet intake in this study were in the same range as those which were found previously to increase food pellet consumption by free feeding rats. The effects of 8-OH-DPAT were also examined in a feeding choice test in which free feeding animals were allowed to choose between food pellets and a liquid chow diet. In this test, 8-OH-DPAT significantly increased total food intake (liquid plus pellet) but had no significant effect on the consumption of either liquid or pellet diets when analysed separately. Thus, there were large individual differences in diet choice after 8-OH-DPAT injection. However, rats did not consistently choose to eat food pellets rather than the liquid diet, as would be predicted if the drug elicited chewing rather than eating. These results provide strong evidence that 8-OH-DPAT elicits a behaviourally specific hyperphagia and not chewing or gnawing.
最近有说法称，5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）会引发对固体食物而非液体食物的咀嚼和进食。因此，研究人员通过让雄性大鼠自由进食，检测了8-OH-DPAT和另一种5-羟色胺1A受体激动剂吉哌隆对液体饲料摄入量的影响。在2小时的测试中，两种药物均使液体饲料的摄入量呈剂量依赖性增加。本研究中增加液体饲料摄入量的8-OH-DPAT和吉哌隆的剂量范围，与先前发现的通过让大鼠自由进食增加食丸摄入量的剂量范围相同。研究人员还在一项进食选择测试中检测了8-OH-DPAT的作用，该测试中让自由进食的动物在食丸和液体饲料之间进行选择。在该测试中，8-OH-DPAT显著增加了总食物摄入量（液体加食丸），但分别分析时，对液体或食丸饲料的摄入量均无显著影响。因此，注射8-OH-DPAT后，饮食选择存在很大的个体差异。然而，大鼠并没有如药物引发咀嚼而非进食所预测的那样，始终选择进食食丸而非液体饲料。这些结果提供了有力证据，表明8-OH-DPAT引发的是行为特异性的食欲亢进，而非咀嚼或啃咬。
