Dourish C T, Cooper S J, Gilbert F, Coughlan J, Iversen S D
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
Psychopharmacology (Berl). 1988;94(1):58-63. doi: 10.1007/BF00735881.
The 5-HT1A agonist 8-OH-DPAT, at a dose of 30 micrograms/kg, enhanced the consumption of sweetened wet mash and sweetened milk in non-deprived rats. In partially satiated rats, sensitivity to the hyperphagic effect of 8-OH-DPAT on wet mash intake was substantially increased, so that the minimally effective dose was reduced to 3 micrograms/kg. Similarly, 8-OH-DPAT was more efficacious in increasing milk intake in satiated rats. Thus, 30 and 40 micrograms/kg 8-OH-DPAT produced a 4-fold increase of milk intake in completely satiated rats compared to a 2-fold increase in partially satiated animals at a dose of 30 micrograms/kg. The increased intake of liquid and wet mash diets observed after treatment with low doses of 8-OH-DPAT argues against the involvement of non-specific gnawing in the increased consumption of solid food produced by the drug. Rather, the data suggest that 8-OH-DPAT may specifically stimulate appetite by counteracting a tonic serotonergic inhibition of feeding. The present experiments also showed that 8-OH-DPAT attenuates fenfluramine-induced anorexia which is thought to depend on increased serotonergic neurotransmission.
5-羟色胺1A受体激动剂8-羟基二丙胺基四氢萘（8-OH-DPAT），剂量为30微克/千克时，可增加未禁食大鼠对加糖湿料和加糖牛奶的摄入量。在部分饱足的大鼠中，8-OH-DPAT对湿料摄入量的促食作用敏感性显著增加，以至于最小有效剂量降至3微克/千克。同样，8-OH-DPAT在增加饱足大鼠的牛奶摄入量方面更有效。因此，与30微克/千克剂量下部分饱足动物2倍的增加量相比，30微克/千克和40微克/千克的8-OH-DPAT可使完全饱足大鼠的牛奶摄入量增加4倍。低剂量8-OH-DPAT治疗后观察到的液体和湿料饮食摄入量增加，表明药物引起的固体食物摄入量增加并非由非特异性啃咬所致。相反，数据表明8-OH-DPAT可能通过抵消5-羟色胺对进食的紧张性抑制作用来特异性刺激食欲。本实验还表明，8-OH-DPAT可减轻芬氟拉明诱导的厌食症，这种厌食症被认为与5-羟色胺能神经传递增加有关。
