Montgomery A M, Willner P, Muscat R
Psychology Department, City of London Polytechnic, UK.
Psychopharmacology (Berl). 1988;94(1):110-4. doi: 10.1007/BF00735890.
8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) has been reported to increase food intake. This effect was confirmed in rats consuming plain or sweetened wet mash. However, the consumption of a 35% sucrose solution or of a range of other flavoured liquids was enhanced marginally if at all by a single low dose of 8-OH-DPAT, and the drug actually decreased the consumption of a high protein liquid diet. 8-OH-DPAT did, however, increase gnawing on a wooden block. These results suggest that 8-OH-DPAT-induced "hyperphagia" may to some extent be secondary to the elicitation of chewing behaviour. 8-OH-DPAT also caused certain other behavioural changes, including a suppression of grooming.
据报道，8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）会增加食物摄入量。在食用普通或加糖湿饲料的大鼠身上证实了这种效果。然而，单剂量低剂量的8-OH-DPAT对35%蔗糖溶液或一系列其他调味液体的摄入量即便有影响也微乎其微，而且该药物实际上还减少了高蛋白液体饮食的摄入量。不过，8-OH-DPAT确实增加了对木块的啃咬。这些结果表明，8-OH-DPAT诱导的“摄食过量”在某种程度上可能继发于咀嚼行为的引发。8-OH-DPAT还引起了其他一些行为变化，包括梳理行为的抑制。
