Pedersen B K, Abom B
Laboratory of Medical Immunology TTA, Rigshospitalet, University Hospital, Copenhagen, Denmark.
Allergy. 1988 Jul;43(5):396-8. doi: 10.1111/j.1398-9995.1988.tb00435.x.
The percentages of CD5+ (pan T), CD8+ (mainly T suppressor) and CD4+ (mainly T helper) cells were studied in 80 patients with rheumatoid arthritis (RA), grouped according to medication into four groups: 1) controls, not receiving remission-inducing therapy, 2) patients on oral gold (triethylphosphine gold, auranofin), 3) patients on parenteral gold (sodium aurothiomalate) and 4) patients on azathioprine. The total number of lymphocytes was not influenced by treatment with auranofin or sodium aurothiomalate, while the number of lymphocytes was depressed in the azathioprine-treated group (P less than 0.01). Neither treatment with azathioprine or parenteral gold, nor treatment with azathioprine influenced the CD4+/CD8+ ratio.
对80例类风湿性关节炎（RA）患者的CD5 +（全T细胞）、CD8 +（主要是抑制性T细胞）和CD4 +（主要是辅助性T细胞）细胞百分比进行了研究，根据用药情况将患者分为四组：1）未接受缓解诱导治疗的对照组；2）口服金制剂（三乙膦金，金诺芬）的患者；3）胃肠外给予金制剂（硫代苹果酸金钠）的患者；4）使用硫唑嘌呤的患者。淋巴细胞总数不受金诺芬或硫代苹果酸金钠治疗的影响，而硫唑嘌呤治疗组的淋巴细胞数量减少（P小于0.01）。硫唑嘌呤或胃肠外给予金制剂的治疗以及硫唑嘌呤治疗均不影响CD4 + / CD8 +比值。
