选择性5-羟色胺再摄取抑制剂相关磨牙症：已发表病例报告的系统评价
SSRI-associated bruxism: A systematic review of published case reports.
作者信息
Garrett Andrew R, Hawley Jason S
机构信息
Department of Neurology, Walter Reed National Military Medical Center, Bethesda, MD.
出版信息
Neurol Clin Pract. 2018 Apr;8(2):135-141. doi: 10.1212/CPJ.0000000000000433.
PURPOSE OF REVIEW
Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports.
RECENT FINDINGS
Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients. Patients may develop symptoms with short-term and long-term antidepressant use. Fluoxetine, sertraline, and venlafaxine were the most commonly reported offending agents. Symptoms may begin within 3-4 weeks of medication initiation and may resolve within 3-4 weeks of drug discontinuation, addition of buspirone, or substitution with another pharmacologic agent. The incidence of this phenomenon is unknown.
SUMMARY
Bruxism associated with antidepressant use is an underrecognized phenomenon among neurologists, and may be treated with the addition of buspirone, dose modification, or medication discontinuation.
综述目的
抗抑郁药相关的运动障碍是一种已被充分描述的现象。然而，抗抑郁药相关的磨牙症、颌面部疼痛或颌面部痉挛，虽然在牙科文献中有报道，但在神经科医生中却较少被认识到。我们通过对病例报告的系统回顾，总结了抗抑郁药相关磨牙症及相关颌面部疼痛的临床特征和治疗方法。
最新发现
抗抑郁药相关磨牙症可能发生在儿童和成人患者中，最常见于女性患者。患者在短期和长期使用抗抑郁药时都可能出现症状。氟西汀、舍曲林和文拉法辛是最常被报道的致病药物。症状可能在开始用药后3 - 4周内出现，并可能在停药、加用丁螺环酮或换用其他药物后3 - 4周内缓解。这种现象的发生率尚不清楚。
总结
抗抑郁药相关磨牙症在神经科医生中是一种未被充分认识的现象，可通过加用丁螺环酮、调整剂量或停药来治疗。
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