Motahari Paria, Katebi Katayoun, Pournaghi-Azar Fatemeh, Jabbarzadeh Masoumeh
Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz university of Medical Sciences, Tabriz, East Azarbaijan, Iran.
Department of Restorative Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, East Azarbaijan, Iran.
Sleep Sci. 2023 Jul 6;16(2):248-255. doi: 10.1055/s-0043-1770811. eCollection 2023 Jun.
Genetic factors may influence sleep bruxism's pathogenesis. Even though the association between the, 5-hydroxytryptamine 2A (5-HTR2A) serotonin receptor gene polymorphism and sleep bruxism has been investigated, inconsistent findings have been discovered. As a result, meta-analysis was performed to gather complete results on this topic. PubMed, Web of Science, Embase, and Scopus databases were searched for all papers containing English abstracts until April 2022. Medical Subject Heading (MESH) terms plus unrestricted keywords were used in the searches. The Cochrane test and the I statistic were used to determine the heterogeneity percentage in numerous researches. Comprehensive Meta-analysis v.2.0 software was used to conduct the analyses. Five properly fitting papers were chosen for meta-analysis from the 39 articles acquired during the initial search. The meta-analysis revealed that the 5-HTR2A polymorphism has no link with sleep bruxism susceptibility across the models studied (P-Value > 0.05). The combined odds ratio analysis revealed no statistically significant association between the 5-HTR2A gene polymorphism with sleep bruxism. Nonetheless, these findings require confirmation through researches with large sample sizes. Identifying genetic markers for sleep bruxism may help clarify and expand our current knowledge of bruxism physiopathology.
遗传因素可能影响磨牙症的发病机制。尽管已经对5-羟色胺2A（5-HTR2A）血清素受体基因多态性与磨牙症之间的关联进行了研究，但结果并不一致。因此，进行了荟萃分析以汇总该主题的完整结果。检索了PubMed、科学网、Embase和Scopus数据库中截至2022年4月所有包含英文摘要的论文。检索中使用了医学主题词（MESH）术语以及不受限制的关键词。采用Cochrane检验和I统计量来确定众多研究中的异质性百分比。使用综合Meta分析v.2.0软件进行分析。从初步检索获得的39篇文章中选择了5篇拟合良好的论文进行荟萃分析。荟萃分析显示，在所研究的模型中，5-HTR2A多态性与磨牙症易感性无关联（P值>0.05）。合并优势比分析显示，5-HTR2A基因多态性与磨牙症之间无统计学显著关联。尽管如此，这些发现需要通过大样本研究来证实。确定磨牙症的遗传标记可能有助于阐明和扩展我们目前对磨牙症生理病理学的认识。
