Shabo Ehab, Zoubaa Saida, Gielen Gerrit H, Clauberg Ralf, Wispel Christian, Pietsch Torsten, Vatter Hartmut, Sarikaya-Seiwert Sevgi
Department of Neurosurgery, Friedrich-Wilhelms-University, University Hospital Bonn, Venusberg-Campus 1, Bonn, 53127, Germany.
Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, 53127, Germany.
Childs Nerv Syst. 2025 Feb 14;41(1):112. doi: 10.1007/s00381-025-06768-7.
A 7-year-old boy presented to the hospital with recurrent nausea and vomiting over 2 weeks. A cranial MRI revealed a large heterogeneous lesion in the posterior fossa extending from the fourth ventricle to the foramen magnum with contact to the brainstem. The lesion showed moderate diffusion restriction and multiple small cystic components. The child underwent gross total resection. The primary histological findings suggested proliferative active tumor without further definition. The extended histological examination 3 weeks later confirmed the diagnosis of astroblastoma. Due to complete resection and full recovery of the patient, watchful waiting with radiological follow-up was recommended. Astroblastoma is an extremely rare tumor especially in the posterior fossa. However, it should be considered as a differential diagnosis in every tumor presenting the discussed radiological and histological features, especially in young aged patients.
一名7岁男孩因持续2周的反复恶心和呕吐入院。头颅磁共振成像（MRI）显示后颅窝有一个大的异质性病变，从第四脑室延伸至枕骨大孔并累及脑干。该病变表现为中度弥散受限和多个小囊状成分。患儿接受了肿瘤全切术。初步组织学检查结果提示为增殖活跃的肿瘤，但未进一步明确。3周后的进一步组织学检查确诊为成星形细胞瘤。鉴于患者已完全切除肿瘤且恢复良好，建议进行影像学随访观察。成星形细胞瘤是一种极其罕见的肿瘤，尤其是发生在后颅窝。然而，对于呈现上述影像学和组织学特征的每一例肿瘤，尤其是年轻患者，都应将其作为鉴别诊断之一。
