State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Renal Division, Department of Internal Medicine, West China Hospital of Sichuan University, Chengdu, China.
PLoS One. 2018 Apr 30;13(4):e0196660. doi: 10.1371/journal.pone.0196660. eCollection 2018.
The study aimed to evaluate the efficacy of the combination of CPP-ACP and fluorides compared with fluorides monotherapy on patients with early caries lesions. The Medline, Embase and Cochrane databases up to August 2017 were scanned, with no restrictions. Studies satisfied the guideline of randomised controlled trials (RCTs), the patients with early caries lesions and data considering the efficacy of fluorides and CPP-ACP versus fluorides alone were selected. There was no language restriction during the literature search process, however, only papers in English or Chinese were included during the selection process. Outcome variables include laser fluorescence, quantitative light-induced fluorescence, lesion area and visual inspection scores. Mean differences were calculated during the data extraction process. Ten studies including 559 patients were selected in the meta-analysis. Fluorides combined with CPP-ACP achieved the same efficacy for early caries lesions on smooth surfaces compared with fluorides monotherapy (mean difference: -13.90, 95% confidence interval: [-39.25, 11.46], P = 0.28), and the combination treatment showed significantly better efficacy than fluorides monotherapy for occlusal early caries lesions (mean difference: -21.02, 95% confidence interval: [-27.94, -14.10], P<0.01). However, further well-designed studies are still needed.
本研究旨在评估 CPP-ACP 与氟化物联合治疗与氟化物单药治疗在早期龋损患者中的疗效。检索了 Medline、Embase 和 Cochrane 数据库，截至 2017 年 8 月，无限制。研究符合随机对照试验 (RCT) 的指南，纳入了早期龋损患者，以及比较氟化物和 CPP-ACP 与氟化物单独使用疗效的数据。文献检索过程中无语言限制，但在选择过程中仅纳入英文或中文文献。结局变量包括激光荧光、定量光诱导荧光、病变面积和肉眼检查评分。数据提取过程中计算了均数差值。荟萃分析纳入了 10 项研究，共 559 例患者。氟化物联合 CPP-ACP 对平滑面早期龋损的疗效与氟化物单药治疗相同（均数差值：-13.90，95%置信区间：[-39.25，11.46]，P=0.28），联合治疗对窝沟早期龋损的疗效明显优于氟化物单药治疗（均数差值：-21.02，95%置信区间：[-27.94，-14.10]，P<0.01）。然而，仍需要进一步设计良好的研究。
